Labs by research area
Gutmann Lab
David H. Gutmann, MD, PhD
Our laboratory employs numerous complementary experimental platforms, including human induced pluripotent stem cells and novel genetically-engineered mouse strains to define the molecular and cellular pathogenesis of pediatric brain tumors and cognitive dysfunction relative to improved risk stratification and treatment strategies for children affected with these nervous system problems.
Holtzman Lab
David Holtzman, MD
A major interest in the Holtzman lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the central nervous system particularly as these mechanisms may relate to Alzheimer’s disease (AD).
Hyrc Lab
Krzysztof Hyrc, PhD
Krzysztof Hyrc, PhD, is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.
Ju Lab
Yo-El Ju, MD, MSCI
The Ju lab studies the relationship between sleep and neurodegenerative diseases through translational and clinical research.
Kotzbauer Lab
Paul Kotzbauer, MD, PhD
The Kotzbauer lab is working to understand mechanisms of neurodegeneration underlying Parkinson’s disease and related disorders. Specific types of pathological neuronal inclusions that occur in Parkinson’s disease also occur in other neurodegenerative diseases, suggesting that common mechanisms of pathogenesis may be involved.
Kress Lab
Geraldine Kress, PhD
My research interests focus on understanding interactions between cognitive function and the circadian system during the aging process and Alzheimer’s disease (AD) progression in order to identify pathophysiology changes, mechanisms, and possible strategies to ameliorate disease progression.
Kummer Lab
Terrance T. Kummer, MD, PhD
Research at the Kummer lab and in our collaborative group is focused on the mechanisms of cellular damage in traumatic brain injury (TBI) and in Alzheimer’s disease, with a particular focus on synaptic and other forms of gray matter injury. TBI is a major cause of morbidity and mortality in the U.S. and worldwide and a major risk factor for the development of Alzheimer’s disease.
Lee Lab
Jin-Moo Lee, MD, PhD
Alzheimer’s disease (AD) is associated with the accumulation of aggregated amyloid-beta peptide (Abeta) in senile plaques within the brain.
Li Lab
Mingjie Li, MD, PhD
The Li lab is developing new vectors for neurological applications. The goal of the Viral Vectors Core is to assist Washington University neuroscience researchers in the design and production of various kinds of vectors.
Lucey Lab
Brendan P. Lucey, MD, MSCI, FAASM
The Lucey lab investigates the relationship between sleep, aging and Alzheimer’s disease. Recent evidence suggests a role for sleep in Alzheimer’s disease pathogenesis and/or as a marker for the onset and/or progression of Alzheimer’s disease that could be followed as an outcome measure in treatment trials. The major goal of our research is use sleep to prevent or delay Alzheimer’s disease.