Hyrc Lab

Krzysztof Hyrc, PhD

Krzysztof Hyrc, PhD, is originally from Krakow, Poland. He received his MSc (summa cum laude) in biology in 1981 and his PhD in cellular biophysics in 1987 from Jagielloniasn University in Krakow, Poland. Hyrc completed his first postdoctoral training at the Department of Physiology and Biophysics, University of Miami, Florida. In 1990, he returned from Miami to his native Krakow and was appointed an instructor at the Institute of Molecular Biology, Jagiellonian University. In 1995, Hyrc came to Washington University School of Medicine to work as a research associate before being appointed a research Instructor in 2001.

Hyrc is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.


Principal investigator

Krzysztof Hyrc, PhD

Associate Professor, Neurology

Recent publications

  • TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte HomeostasisMa, X., Rawnsley, D. R., Kovacs, A., Islam, M., Murphy, J. T., Zhao, C., Kumari, M., Foroughi, L., Liu, H., Qi, K., Diwan, A., Hyrc, K., Evans, S., Satoh, T., French, B. A., Margulies, K. B., Javaheri, A., Razani, B., Mann, D., Mani, K., & 1 othersDiwan, A., Mar 2022, In: JACC: Basic to Translational Science. 7, 3, p. 223-243 21 p.Research output: Contribution to journal › Article › peer-review
  • TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagyJavaheri, A., Bajpai, G., Picataggi, A., Mani, S., Foroughi, L., Evie, H., Kovacs, A., Weinheimer, C. J., Hyrc, K., Xiao, Q., Ballabio, A., Lee, J. M., Matkovich, S. J., Razani, B., Schilling, J. D., Lavine, K. J. & Diwan, A., Nov 1 2019, In: JCI Insight. 4, 21, e127312.Research output: Contribution to journal › Article › peer-review
  • Beta-cell excitability and excitability-driven diabetes in adult Zebrafish isletsEmfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D. W., Hyrc, K., Remedi, M. S. & Nichols, C. G., Jun 2019, In: Physiological Reports. 7, 11, e14101.Research output: Contribution to journal › Article › peer-review
  • Regulation of insulin receptor pathway and glucose metabolism by CD36 signalingSamovski, D., Dhule, P., Pietka, T., Jacome-Sosa, M., Penrose, E., Son, N. H., Flynn, C. R., Shoghi, K. I., Hyrc, K. L., Goldberg, I. J., Gamazon, E. R. & Abumrad, N. A., Jul 2018, In: Diabetes. 67, 7, p. 1272-1284 13 p.Research output: Contribution to journal › Article › peer-review
  • Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathwayLiu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K., Saftig, P., Marshall, C., McDaniel, M. L., Remedi, M. S., Razani, B., Urano, F. & Diwan, A., Nov 2 2017, In: Autophagy. 13, 11, p. 1952-1968 17 p.Research output: Contribution to journal › Article › peer-review

Contact Us

Principal Investigator

Krzysztof Hyrc, PhD
Voice: 314-362-3259
Fax: 314-362-9462
Email: hyrck@wustl.edu

U.S. mail

Hyrc Lab
Department of Neurology
660 South Euclid
Campus Box 8111
St. Louis, MO 63110