The Department of Neurology runs a large number of clinical trials in nearly every subspecialty of neurology. Below is a list of the department’s current clinical trials.
About participating
What is a clinical trial? Clinical trials are organized experiments performed on human participants to determine the best way to treat, diagnose or prevent a disease. The information that scientists learn from clinical trials helps to improve the medical care for future patients. Clinical studies are carefully and ethically designed to protect participants from unnecessary side effects and other risks. Most clinical research is federally regulated with built-in safeguards to protect the participants.
Active clinical trials
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, Familial Interventions: Drug: Gantenerumab Sponsors: Washington University School of Medicine; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA) Terminated
- Conditions: Alzheimer's Disease; Dementia; Alzheimer's Disease, Familial Interventions: Drug: lecanemab Sponsors: Washington University School of Medicine; Alzheimer's Association; Eisai Inc. Recruiting
- Conditions: Cognitive Impairment; Dementia Interventions: Other: No interventions Sponsors: Massachusetts General Hospital; Duke University; Johns Hopkins University; University of New Mexico; University of Southern California; University of Kentucky; Rush University Medical Center; University of Maryland, Baltimore; University of California, San Francisco; University of California, Los Angeles; University of California, Davis; University of Texas; The University of Texas Health Science Center at San Antonio; The University of Texas Health Science Center, Houston; Mayo Clinic; University of Mississippi Medical Center; Washington University School of Medicine; Olive View-UCLA Education & Research Institute Recruiting
- Conditions: Alzheimer Disease Interventions: Drug: Lemborexant 10 mg; Drug: Lemborexant 20mg; Drug: Placebo Sponsors: Washington University School of Medicine; National Institutes of Health (NIH); Eisai Inc.; National Institute on Aging (NIA) Recruiting
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, Familial Interventions: Drug: Gantenerumab; Drug: Matching Placebo (Gantenerumab) Sponsors: Washington University School of Medicine; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA); Genentech, Inc. Not yet recruiting
- Conditions: Alzheimer Disease Interventions: Drug: 18F-Flortaucipir radiopharmaceutical; Drug: 18F-MK-6240 radiopharmaceutical; Drug: Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694 or 18F-Florbetapir) Sponsors: Tharick Pascoal; National Institute on Aging (NIA) Recruiting
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, Familial Interventions: Drug: E2814; Drug: Lecanemab; Drug: Matching Placebo (E2814) Sponsors: Washington University School of Medicine; Alzheimer's Association; National Institute on Aging (NIA); Accelerating Medicines Partnership (AMP); Eisai Inc. Active, not recruiting
- Conditions: Alzheimer Disease; Obesity; Metabolic Disease Sponsors: Cyrus A Raji Recruiting
- Conditions: Alzheimer Disease; Dementia of Alzheimer Type Interventions: Other: Arm A , Arm B, Arm C, & Arm D Sponsors: Washington University School of Medicine Active, not recruiting
- Conditions: Frontotemporal Dementia; Frontotemporal Lobar Degeneration; FTD-GRN Sponsors: The Bluefield Project to Cure Frontotemporal Dementia; Mayo Clinic; University of California, San Francisco Active, not recruiting
- Conditions: Cognitive Impairment, Mild; Dementia; Cardiovascular Diseases Interventions: Drug: Atorvastatin 40 Mg Oral Tablet; Drug: Placebo oral tablet Sponsors: Duke University; National Institute on Aging (NIA); National Heart, Lung, and Blood Institute (NHLBI); Wake Forest University Health Sciences Recruiting
- Conditions: Parkinsons Interventions: Radiation: PiB and VAT Sponsors: Washington University School of Medicine; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA) Recruiting
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, Familial Interventions: Drug: Gantenerumab; Drug: Solanezumab; Drug: Matching Placebo (Gantenerumab); Drug: Matching Placebo (Solanezumab); Drug: Gantenerumab; Drug: E2814; Drug: Lecanemab; Drug: Matching Placebo (E2814) Sponsors: Washington University School of Medicine; Eli Lilly and Company; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA); Avid Radiopharmaceuticals; Accelerating Medicines Partnership (AMP); Eisai Inc.; Janssen, LP Recruiting
- Conditions: Huntington's Disease Sponsors: CHDI Foundation, Inc. Recruiting
- Conditions: Alzheimer's Disease Sponsors: Washington University School of Medicine; National Institute on Aging (NIA) Recruiting
For a more comprehensive list of our Alzheimer disease clinical trials, please visit the Knight ADRC website, the Knight ADRC Clinical Trials Unit website and DIAN website.
- Conditions: Focal Onset Seizures Interventions: Drug: XEN1101; Drug: Placebo Sponsors: Xenon Pharmaceuticals Inc.; Worldwide Clinical Trials Recruiting
- Conditions: Tuberous Sclerosis Complex Interventions: Drug: Early Vigabatrin; Drug: Delayed Vigabatrin (Placebo) Sponsors: Martina Bebin; National Institute of Neurological Disorders and Stroke (NINDS) Completed
- Conditions: Tauopathies Interventions: Diagnostic Test: Amyloid PET scan; Diagnostic Test: Brain MRI Scan; Behavioral: Neurologic exam Sponsors: University of Pennsylvania Recruiting
- Conditions: Parkinson Disease; Multiple System Atrophy, Parkinson Variant; Progressive Supranuclear Palsy Interventions: Diagnostic Test: AIDP Sponsors: University of Florida; Augusta University; Albany Medical College; Beth Israel Deaconess Medical Center; Duke University; Johns Hopkins University; Massachusetts General Hospital; Northwestern University; Ottawa Hospital Research Institute; Penn State University; University of Alabama at Birmingham; University of California, San Diego; University of California, San Francisco; University of Chicago; University of Michigan; University of Minnesota; University of South Florida; Centre for Addiction and Mental Health; Wake Forest University; Washington University School of Medicine; University of Kentucky; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
- Conditions: Primary Ciliary Dyskinesia; Kartagener Syndrome Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati Recruiting
- Conditions: Primary Ciliary Dyskinesia; Kartagener Syndrome; Primary Immune Deficiency Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati; National Heart, Lung, and Blood Institute (NHLBI) Recruiting
- Conditions: Primary Ciliary Dyskinesia; Primary Immune Deficiency; Kartagener Syndrome Interventions: Diagnostic Test: Genetic Testing for PCD or PID; Other: Unaffected Family Member Genetic Testing Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati Recruiting
- Conditions: Parkinsons Interventions: Radiation: PiB and VAT Sponsors: Washington University School of Medicine; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA) Recruiting
- Conditions: Huntington's Disease Sponsors: CHDI Foundation, Inc. Recruiting
- Conditions: Tuberous Sclerosis; Lymphangioleiomyomatosis Interventions: Procedure: Phlebotomy; Procedure: Buccal (cheek) swab; Genetic: Genetic Testing; Other: Tissue donation after routine clinical procedure Sponsors: National Tuberous Sclerosis Association Recruiting
- Conditions: Multiple Sclerosis Interventions: Diagnostic Test: MRI Sponsors: The Cleveland Clinic; National Institute of Neurological Disorders and Stroke (NINDS); University of Pennsylvania; Cedars-Sinai Medical Center; National Institutes of Health (NIH) Active, not recruiting
- Conditions: Relapsing Remitting Multiple Sclerosis Interventions: Other: Intermittent fasting Sponsors: Washington University School of Medicine Completed
- Conditions: Primary Progressive Multiple Sclerosis; Secondary Progressive Multiple Sclerosis Interventions: Biological: ATA188; Drug: Placebo Sponsors: Atara Biotherapeutics Terminated
- Conditions: Tuberous Sclerosis Complex Interventions: Drug: Early Vigabatrin; Drug: Delayed Vigabatrin (Placebo) Sponsors: Martina Bebin; National Institute of Neurological Disorders and Stroke (NINDS) Completed
- Conditions: Spinal and Bulbar Muscular Atrophy; Kennedy's Disease Interventions: Drug: AJ201; Drug: Placebo Sponsors: AnnJi Pharmaceutical Co., Ltd. Completed
- Conditions: Spinal Muscular Atrophy; Neuromuscular Diseases; SMA Interventions: Drug: taldefgrobep alfa; Drug: Placebo; Drug: taldefgrobep alfa Sponsors: Biohaven Pharmaceuticals, Inc. Active, not recruiting
- Conditions: Spinal Muscular Atrophy Interventions: Drug: Risdiplam Sponsors: Genentech, Inc. Recruiting
- Conditions: Sporadic Inclusion Body Myositis; Inclusion Body Myositis Sponsors: University of California, Irvine; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Active, not recruiting
- Conditions: Cubital Tunnel Syndrome; Nerve Compression; Nerve Injury; Ulnar Neuropathies Interventions: Device: Checkpoint BEST System Sponsors: Checkpoint Surgical Inc.; Congressionally Directed Medical Research Programs Recruiting
- Conditions: Muscular Dystrophy, Duchenne Interventions: Genetic: delandistrogene moxeparvovec Sponsors: Sarepta Therapeutics, Inc.; Hoffmann-La Roche Active, not recruiting
- Conditions: Neuropathic Pain Interventions: Drug: Ondansetron 16 mg with Tariquidar; Drug: Ondansetron 16 mg with Placebo Sponsors: Washington University School of Medicine Completed
- Conditions: Cubital Tunnel Syndrome; Peroneal Nerve Entrapment Interventions: Device: Mechanomyography (MMG) Sponsors: Washington University School of Medicine; Mayo Clinic Completed
- Conditions: Amyotrophic Lateral Sclerosis, Familial; Amyotrophic Lateral Sclerosis, Sporadic Sponsors: Washington University School of Medicine; Massachusetts General Hospital Suspended
- Conditions: Duchenne Muscular Dystrophy Interventions: Drug: Pamrevlumab Sponsors: FibroGen Terminated
- Conditions: Sarcoma; Malignant Peripheral Nerve Sheath Tumors Interventions: Drug: PLX3397; Drug: Sirolimus Sponsors: Gulam Manji; Daiichi Sankyo Active, not recruiting
- Conditions: Amyotrophic Lateral Sclerosis; Lou Gehrig's Disease Interventions: Drug: coenzyme Q10; Drug: Placebo Sponsors: Columbia University; National Institute of Neurological Disorders and Stroke (NINDS) Completed
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- Conditions: Spinal and Bulbar Muscular Atrophy; Kennedy's Disease Interventions: Drug: AJ201; Drug: Placebo Sponsors: AnnJi Pharmaceutical Co., Ltd. Completed
- Conditions: Spinal Muscular Atrophy; Neuromuscular Diseases; SMA Interventions: Drug: taldefgrobep alfa; Drug: Placebo; Drug: taldefgrobep alfa Sponsors: Biohaven Pharmaceuticals, Inc. Active, not recruiting
- Conditions: Spinal Muscular Atrophy Interventions: Drug: Risdiplam Sponsors: Genentech, Inc. Recruiting
- Conditions: Muscular Dystrophy, Duchenne Interventions: Genetic: delandistrogene moxeparvovec Sponsors: Sarepta Therapeutics, Inc.; Hoffmann-La Roche Active, not recruiting
- Conditions: Duchenne Muscular Dystrophy Interventions: Drug: Pamrevlumab Sponsors: FibroGen Terminated
- Conditions: Alzheimer Disease Interventions: Drug: Lemborexant 10 mg; Drug: Lemborexant 20mg; Drug: Placebo Sponsors: Washington University School of Medicine; National Institutes of Health (NIH); Eisai Inc.; National Institute on Aging (NIA) Recruiting
- Conditions: Treatment Resistant Depression Interventions: Diagnostic Test: Electroencephalography (EEG); Diagnostic Test: Quantitative Measurements of Sleep Microstructure Sponsors: Washington University School of Medicine; National Institute of Mental Health (NIMH) Recruiting
- Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter Trial Interventions: Device: CPAP Sponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of Cincinnati Recruiting
- Conditions: Postoperative Delirium Sponsors: Washington University School of Medicine Active, not recruiting
- Conditions: Dysphagia; Stroke, Acute Interventions: Diagnostic Test: BJH-SDS Screenint Test; Diagnostic Test: Flexible Endoscopic Evaluation of Swallowing Sponsors: University of Giessen Recruiting
- Conditions: Hypoxia-Ischemia, Brain Interventions: Device: taVNS Sponsors: Washington University School of Medicine Enrolling by invitation
- Conditions: Ischemic Stroke Interventions: Biological: TS23 Sponsors: Translational Sciences, Inc.; University of Cincinnati; National Institute of Neurological Disorders and Stroke (NINDS); Medical University of South Carolina; University of Arizona Recruiting
- Conditions: Stroke; Intracranial Atherosclerotic Stenosis (ICAS) Interventions: Other: MRI Sponsors: Yale University; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
- Conditions: Carotid Atherosclerosis; Asymptomatic Carotid Artery Stenosis; Carotid Artery Atheroma Interventions: Drug: 64Cu-25%-CANF-Comb; Drug: 64Cu-25%-CANF-Comb Sponsors: Washington University School of Medicine; Cedars-Sinai Medical Center; University of California, Santa Barbara; National Heart, Lung, and Blood Institute (NHLBI) Recruiting
- Conditions: Prevention of Ischemic Stroke; Acute Non-cardioembolic Ischemic Stroke; High-risk Transient Ischemic Attack Interventions: Drug: Asundexian (BAY2433334); Drug: Placebo Sponsors: Bayer Recruiting
- Conditions: Intra Cerebral Hemorrhage; ICH – Intracerebral Hemorrhage; ICH; Hemorrhage; Stroke; Clot (Blood); Brain; Clot Blood; Cognitive Decline; Cognitive Impairment; Survivorship; Memory Impairment; Motor Activity Sponsors: Johns Hopkins University; National Institute of Neurological Disorders and Stroke (NINDS) Enrolling by invitation
- Conditions: Acute Ischemic Stroke Interventions: Device: transcutaneous auricular vagal nerve stimulation; Device: Sham transcutaneous vagal nerve stimulation Sponsors: Washington University School of Medicine Recruiting
- Conditions: Intracranial Arteriosclerosis; Stroke Interventions: Drug: Ticagrelor + Aspirin; Drug: Rivaroxaban + Aspirin; Drug: Clopidogrel + Aspirin; Other: Risk Factor Management Sponsors: University of Florida; National Institute of Neurological Disorders and Stroke (NINDS); University of Cincinnati; Medical University of South Carolina; Janssen Scientific Affairs, LLC; AstraZeneca Recruiting
- Conditions: Stroke; Thromboses, Intracranial; Aneurysm, Brain Interventions: Procedure: Stroke/Thrombectomy/Aneurysm-specific surgical procedures Sponsors: Medical University of South Carolina Recruiting
- Conditions: Supratentorial Hemorrhage Interventions: Device: Aurora Surgiscope System Sponsors: Integra LifeSciences Corporation; Icahn School of Medicine at Mount Sinai; Oculus Imaging LLC Recruiting
- Conditions: Subdural Hematoma Interventions: Procedure: Surgical Management; Device: Surgical Management + Treatment; Other: No Treatment; Device: Treatment Sponsors: Medtronic Neurovascular Clinical Affairs Active, not recruiting
- Conditions: Intracerebral Hemorrhage Interventions: Drug: Statins Sponsors: Beth Israel Deaconess Medical Center; NINDS Stroke Trials Network (StrokeNet); Canadian Stroke Consortium (CSC); University of Cincinnati; Medical University of South Carolina; Yale University; MetroHealth Medical Center; UH, Cleveland Medical Center; Spectrum Health Hospitals; West Virginia University; Columbia University; Weill Medical College of Cornell University; New York Presbyterian Brooklyn Methodist Hospital; Buffalo General Medical Center; State University of New York – Upstate Medical University; St. Joseph's Regional Medical Center, New Jersey; Tufts Medical Center; Massachusetts General Hospital; UMASS Memorial Medical Center; Brigham and Women's Hospital; Baystate Medical Center; University of Vermont Medical Center; […]
- Conditions: Intracerebral Hemorrhage; Atrial Fibrillation Interventions: Drug: Apixaban; Drug: Aspirin Sponsors: Yale University; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
- Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter Trial Interventions: Device: CPAP Sponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of Cincinnati Recruiting
- Conditions: Acute Ischemic Stroke Interventions: Drug: Argatroban; Drug: Eptifibatide; Drug: Placebo Sponsors: Washington University School of Medicine; National Institute of Neurological Disorders and Stroke (NINDS) Active, not recruiting
- Conditions: Cerebral Stroke Interventions: Device: EmboTrap® Revascularization Device; Device: CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter; Device: CEREGLIDE 71 Intermediate Catheter Sponsors: Cerenovus, Part of DePuy Synthes Products, Inc. Recruiting
- Conditions: Intracerebral Hemorrhage Interventions: Biological: Recombinant Activated Factor VII (rFVIIa); Biological: Placebo Sponsors: Joseph Broderick, MD; Novo Nordisk A/S; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
A patient’s story
Seeking a cure for future ALS patients — “I care, and I want to help.”