The Department of Neurology runs a large number of clinical trials in nearly every subspecialty of neurology. Below is a list of the department’s current clinical trials.

About participating

What is a clinical trial? Clinical trials are organized experiments performed on human participants to determine the best way to treat, diagnose or prevent a disease. The information that scientists learn from clinical trials helps to improve the medical care for future patients. Clinical studies are carefully and ethically designed to protect participants from unnecessary side effects and other risks. Most clinical research is federally regulated with built-in safeguards to protect the participants.

Active clinical trials

Aging and dementia

For a more comprehensive list of our Alzheimer disease clinical trials, please visit the Knight ADRC website, the Knight ADRC Clinical Trials Unit website and DIAN website.

Epilepsy and seizure disorders
Movement disorders
  • Conditions:   Primary Ciliary Dyskinesia;   Kartagener SyndromeIntervention:   Sponsors:   University of North Carolina, Chapel Hill;   Washington University School of Medicine;   Children's Hospital Colorado;   Stanford University;   Seattle Children's Hospital;   The Hospital for Sick Children;   McGill University;   Children's Hospital Medical Center, CincinnatiRecruiting
  • Conditions:   Primary Ciliary Dyskinesia;   Kartagener Syndrome;   Primary Immune DeficiencyIntervention:   Sponsors:   University of North Carolina, Chapel Hill;   Washington University School of Medicine;   The Hospital for Sick Children;   McGill University;   Children's Hospital Medical Center, Cincinnati;   National Heart, Lung, and Blood Institute (NHLBI)Recruiting
  • Conditions:   Primary Ciliary Dyskinesia;   Primary Immune Deficiency;   Kartagener SyndromeInterventions:   Diagnostic Test: Genetic Testing for PCD or PID;   Other: Unaffected Family Member Genetic TestingSponsors:   University of North Carolina, Chapel Hill;   Washington University School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Children's Hospital Colorado;   Stanford University;   Seattle Children's Hospital;   The Hospital for Sick Children;   McGill University;   Children's Hospital Medical Center, CincinnatiRecruiting
  • Conditions:   Parkinson Disease;   Sleep Disorder;   FatigueIntervention:   Device: SunRay Light BoxesSponsor:   Massachusetts General HospitalActive, not recruiting
  • Conditions:   Progressive Supranuclear Palsy (PSP);   Corticobasal Degeneration (CBD);   Frontotemporal Dementia (FTD MAPT Mutation)Intervention:   Other: 13C6 LeucineSponsors:   Washington University School of Medicine;   Association of Frontotemporal Degeneration;   Tau ConsortiumCompleted
  • Condition:   Parkinson DiseaseIntervention:   Behavioral: Physical TherapySponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Completed
  • Condition:   ParkinsonsIntervention:   Radiation: PiB and VATSponsors:   Washington University School of Medicine;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)Recruiting
  • Condition:   Huntington's DiseaseIntervention:   Sponsor:   CHDI Foundation, Inc.Recruiting
Multiple sclerosis (MS)
Neuromuscular disorders
Neuropsychiatric disorders
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Neurorehabilitation
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Pediatric neurology
Sleep medicine
  • Conditions:   Parkinson Disease;   Sleep Disorder;   FatigueIntervention:   Device: SunRay Light BoxesSponsor:   Massachusetts General HospitalActive, not recruiting
  • Conditions:   Obstructive Sleep Apnea;   TonsillitisInterventions:   Drug: Hydromorphone;   Drug: FentanylSponsor:   Washington University School of MedicineCompleted
  • Conditions:   Sleep;   Sedation ComplicationInterventions:   Radiation: MRI;   Diagnostic Test: Quantitative Sensory Testing (QST);   Diagnostic Test: Home sleep study;   Other: Acoustic stimulation (65db) up-slope of EEG with QST;   Other: Acoustic stimulation (65db) down-slope of EEG with QST;   Other: 0 db with QST;   Drug: Dexmedetomidine;   Other: Breathe-Squeeze TaskSponsor:   Washington University School of MedicineActive, not recruiting
  • Conditions:   Ischemic Stroke;   Sleep Apnea;   Sleep Apnea, Obstructive;   TIA;   Stroke;   CPAP;   Telemedicine;   Home Sleep Apnea Test;   Randomized Clinical Trial;   Multicenter TrialIntervention:   Device: CPAPSponsors:   University of Michigan;   National Institute of Neurological Disorders and Stroke (NINDS);   FusionHealth LLC;   Medical University of South Carolina;   University of CincinnatiRecruiting
  • Conditions:   Heart Failure;   Central Sleep ApneaInterventions:   Drug: Oxygen;   Other: Room AirSponsors:   Brigham and Women's Hospital;   Ohio State UniversityTerminated
  • Conditions:   Heart Failure;   Defibrillators, Implantable;   Monitoring, Physiologic;   Cardiac Resynchronization Therapy;   Cardiovascular Disease;   Heart DiseaseIntervention:   Device: HeartLogic SensorsSponsor:   Boston Scientific CorporationCompleted
  • Condition:   Postoperative DeliriumIntervention:   Sponsor:   Washington University School of MedicineActive, not recruiting
  • Conditions:   Mild Cognitive Impairment;   Sleep Apnea, ObstructiveIntervention:   Device: CPAPSponsors:   University of Pennsylvania;   National Institute on Aging (NIA)Active, not recruiting
  • Conditions:   Congestive Heart Failure;   Chronic Obstructive Pulmonary Disease;   Cancer;   Diabetes Mellitus;   Obstructive Sleep ApneaInterventions:   Other: Early warning system monitoring.;   Other: routine careSponsors:   Washington University School of Medicine;   The Foundation for Barnes-Jewish Hospital;   American College of Chest PhysiciansCompleted
Stroke and cerebrovascular disease
A patient’s story

Seeking a cure for future ALS patients — “I care, and I want to help.”