The Department of Neurology runs a large number of clinical trials in nearly every subspecialty of neurology. Below is a list of the department’s current clinical trials.

About participating

What is a clinical trial? Clinical trials are organized experiments performed on human participants to determine the best way to treat, diagnose or prevent a disease. The information that scientists learn from clinical trials helps to improve the medical care for future patients. Clinical studies are carefully and ethically designed to protect participants from unnecessary side effects and other risks. Most clinical research is federally regulated with built-in safeguards to protect the participants.

Active clinical trials

Aging and dementia

For a more comprehensive list of our Alzheimer disease clinical trials, please visit the Knight ADRC website, the Knight ADRC Clinical Trials Unit website and DIAN website.

Epilepsy and seizure disorders
Movement disorders
  • Conditions: Tauopathies Interventions: Diagnostic Test: Amyloid PET scan; Diagnostic Test: Brain MRI Scan; Behavioral: Neurologic exam Sponsors: University of Pennsylvania Recruiting
  • Conditions: Parkinson Disease; Multiple System Atrophy, Parkinson Variant; Progressive Supranuclear Palsy Interventions: Diagnostic Test: AIDP Sponsors: University of Florida; Augusta University; Albany Medical College; Beth Israel Deaconess Medical Center; Duke University; Johns Hopkins University; Massachusetts General Hospital; Northwestern University; Ottawa Hospital Research Institute; Penn State University; University of Alabama at Birmingham; University of California, San Diego; University of California, San Francisco; University of Chicago; University of Michigan; University of Minnesota; University of South Florida; Centre for Addiction and Mental Health; Wake Forest University; Washington University School of Medicine; University of Kentucky; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
  • Conditions: Primary Ciliary Dyskinesia; Kartagener Syndrome Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati Recruiting
  • Conditions: Primary Ciliary Dyskinesia; Kartagener Syndrome; Primary Immune Deficiency Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati; National Heart, Lung, and Blood Institute (NHLBI) Recruiting
  • Conditions: Primary Ciliary Dyskinesia; Primary Immune Deficiency; Kartagener Syndrome Interventions: Diagnostic Test: Genetic Testing for PCD or PID; Other: Unaffected Family Member Genetic Testing Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati Recruiting
  • Conditions: Parkinson Disease Interventions: Behavioral: Physical Therapy Sponsors: Washington University School of Medicine; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Completed
  • Conditions: Parkinsons Interventions: Radiation: PiB and VAT Sponsors: Washington University School of Medicine; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA) Recruiting
  • Conditions: Huntington's Disease Sponsors: CHDI Foundation, Inc. Recruiting
Multiple sclerosis (MS)
  • Conditions: Multiple Sclerosis; Depression Interventions: Other: Neuro-QoL T-score determination Sponsors: Washington University School of Medicine; University of Connecticut; University of Texas Recruiting
  • Conditions: Tuberous Sclerosis; Lymphangioleiomyomatosis Interventions: Procedure: Phlebotomy; Procedure: Buccal (cheek) swab; Genetic: Genetic Testing; Other: Tissue donation after routine clinical procedure Sponsors: National Tuberous Sclerosis Association Recruiting
  • Conditions: Multiple Sclerosis Interventions: Device: SOMAscan Sponsors: Washington University School of Medicine; National Institute of Allergy and Infectious Diseases (NIAID); University of Colorado, Denver; University of Ottawa; Montana State University Active, not recruiting
  • Conditions: Relapsing Remitting Multiple Sclerosis Interventions: Other: Intermittent fasting Sponsors: Washington University School of Medicine Completed
  • Conditions: Primary Progressive Multiple Sclerosis; Secondary Progressive Multiple Sclerosis Interventions: Biological: ATA188; Drug: Placebo Sponsors: Atara Biotherapeutics Terminated
  • Conditions: Tuberous Sclerosis Complex Interventions: Drug: Vigabatrin; Drug: Placebo Sponsors: Martina Bebin; National Institute of Neurological Disorders and Stroke (NINDS) Completed
Neuromuscular disorders
Neuropsychiatric disorders
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Neurorehabilitation
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Pediatric neurology
Sleep medicine
Stroke and cerebrovascular disease
  • Conditions: Hypoxia-Ischemia, Brain Interventions: Device: taVNS Sponsors: Washington University School of Medicine Enrolling by invitation
  • Conditions: Carotid Atherosclerosis; Asymptomatic Carotid Artery Stenosis; Carotid Artery Atheroma Interventions: Drug: 64Cu-25%-CANF-Comb; Drug: 64Cu-25%-CANF-Comb Sponsors: Washington University School of Medicine; Cedars-Sinai Medical Center; University of California, Santa Barbara; National Heart, Lung, and Blood Institute (NHLBI) Recruiting
  • Conditions: Prevention of Ischemic Stroke; Acute Non-cardioembolic Ischemic Stroke; High-risk Transient Ischemic Attack Interventions: Drug: Asundexian (BAY2433334); Drug: Placebo Sponsors: Bayer Recruiting
  • Conditions: Intra Cerebral Hemorrhage; ICH – Intracerebral Hemorrhage; ICH; Hemorrhage; Stroke; Clot (Blood); Brain; Clot Blood; Cognitive Decline; Cognitive Impairment; Survivorship; Memory Impairment; Motor Activity Sponsors: Johns Hopkins University; National Institute of Neurological Disorders and Stroke (NINDS) Enrolling by invitation
  • Conditions: Acute Ischemic Stroke Interventions: Device: transcutaneous auricular vagal nerve stimulation; Device: Sham transcutaneous vagal nerve stimulation Sponsors: Washington University School of Medicine Recruiting
  • Conditions: Sickle Cell Disease Interventions: Other: Crizanlizumab Sponsors: Andria Ford; Novartis Pharmaceuticals Recruiting
  • Conditions: Intracranial Arteriosclerosis; Stroke Interventions: Drug: Ticagrelor + Aspirin; Drug: Rivaroxaban + Aspirin; Drug: Clopidogrel + Aspirin; Other: Risk Factor Management Sponsors: University of Florida; National Institute of Neurological Disorders and Stroke (NINDS); University of Cincinnati; Medical University of South Carolina; Janssen Scientific Affairs, LLC; AstraZeneca Recruiting
  • Conditions: Stroke; Thromboses, Intracranial; Aneurysm, Brain Interventions: Procedure: Stroke/Thrombectomy/Aneurysm-specific surgical procedures Sponsors: Medical University of South Carolina Recruiting
  • Conditions: Supratentorial Hemorrhage Interventions: Device: Aurora Surgiscope System Sponsors: Integra LifeSciences Corporation; Icahn School of Medicine at Mount Sinai; Oculus Imaging LLC Recruiting
  • Conditions: Subdural Hematoma Interventions: Procedure: Surgical Management; Device: Surgical Management + Treatment; Other: No Treatment; Device: Treatment Sponsors: Medtronic Neurovascular Clinical Affairs Recruiting
  • Conditions: Intracerebral Hemorrhage Interventions: Drug: Statins Sponsors: Beth Israel Deaconess Medical Center; NINDS Stroke Trials Network (StrokeNet); Canadian Stroke Consortium (CSC); University of Cincinnati; Medical University of South Carolina; Yale University; MetroHealth Medical Center; UH, Cleveland Medical Center; Spectrum Health Hospitals; West Virginia University; Columbia University; Weill Medical College of Cornell University; New York Presbyterian Brooklyn Methodist Hospital; Buffalo General Medical Center; State University of New York – Upstate Medical University; St. Joseph's Regional Medical Center, New Jersey; Tufts Medical Center; Massachusetts General Hospital; UMASS Memorial Medical Center; Brigham and Women's Hospital; Baystate Medical Center; University of Vermont Medical Center; […]
  • Conditions: Intracerebral Hemorrhage; Atrial Fibrillation Interventions: Drug: Apixaban; Drug: Aspirin Sponsors: Yale University; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
  • Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; TIA; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter Trial Interventions: Device: CPAP Sponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of Cincinnati Recruiting
  • Conditions: Acute Ischemic Stroke Interventions: Drug: Argatroban; Drug: Eptifibatide; Drug: Placebo Sponsors: Washington University School of Medicine; National Institute of Neurological Disorders and Stroke (NINDS) Active, not recruiting
  • Conditions: Cerebral Stroke Interventions: Device: EmboTrap® Revascularization Device; Device: CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter Sponsors: Cerenovus, Part of DePuy Synthes Products, Inc. Recruiting
  • Conditions: Intracerebral Hemorrhage Interventions: Biological: Recombinant Activated Factor VII (rFVIIa); Biological: Placebo Sponsors: Joseph Broderick, MD; Novo Nordisk A/S; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
  • Conditions: Stroke Interventions: Drug: Apixaban; Drug: Aspirin Sponsors: Columbia University; National Institute of Neurological Disorders and Stroke (NINDS); University of Cincinnati; Medical University of South Carolina; Bristol-Myers Squibb; Pfizer; Roche Pharma AG; Weill Medical College of Cornell University; University of Washington Terminated
A patient’s story

Seeking a cure for future ALS patients — “I care, and I want to help.”