The Department of Neurology runs a large number of clinical trials in nearly every subspecialty of neurology. Below is a list of the department’s current clinical trials.
About participating
What is a clinical trial? Clinical trials are organized experiments performed on human participants to determine the best way to treat, diagnose or prevent a disease. The information that scientists learn from clinical trials helps to improve the medical care for future patients. Clinical studies are carefully and ethically designed to protect participants from unnecessary side effects and other risks. Most clinical research is federally regulated with built-in safeguards to protect the participants.
Active clinical trials
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, FamilialInterventions: Drug: Gantenerumab; Drug: Matching Placebo (Gantenerumab)Sponsors: Washington University School of Medicine; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA); Genentech, Inc.Suspended
- Condition: Alzheimer DiseaseInterventions: Drug: 18F-Flortaucipir radiopharmaceutical; Drug: 18F-MK-6240 radiopharmaceutical; Drug: Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694)Sponsors: Tharick Pascoal; National Institute on Aging (NIA)Recruiting
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, FamilialInterventions: Drug: E2814; Drug: Lecanemab; Drug: Matching Placebo (E2814)Sponsors: Washington University School of Medicine; Alzheimer's Association; National Institute on Aging (NIA); Accelerating Medicines Partnership (AMP); Eisai Inc.Recruiting
- Conditions: Alzheimer Disease; Obesity; Metabolic DiseaseIntervention: Sponsor: Cyrus A RajiRecruiting
- Conditions: Alzheimer Disease; Dementia of Alzheimer TypeIntervention: Other: Arm A , Arm B, Arm C, & Arm DSponsor: Washington University School of MedicineEnrolling by invitation
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, FamilialInterventions: Drug: Gantenerumab; Drug: Solanezumab; Drug: Matching Placebo (Gantenerumab); Drug: Matching Placebo (Solanezumab)Sponsors: Washington University School of Medicine; Eli Lilly and Company; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA); Avid Radiopharmaceuticals; Accelerating Medicines Partnership (AMP)Completed
- Condition: Alzheimer DiseaseInterventions: Drug: GV-971; Drug: PlaceboSponsor: Green Valley (Shanghai) Pharmaceuticals Co., Ltd.Suspended
- Conditions: Frontotemporal Dementia; Frontotemporal Lobar Degeneration; FTD-GRNIntervention: Sponsors: The Bluefield Project to Cure Frontotemporal Dementia; Mayo Clinic; University of California, San FranciscoRecruiting
- Conditions: Cognitive Impairment, Mild; Dementia; Cardiovascular DiseasesInterventions: Drug: Atorvastatin 40 Mg Oral Tablet; Drug: Placebo oral tabletSponsors: Duke University; National Institute on Aging (NIA); National Heart, Lung, and Blood Institute (NHLBI); Wake Forest University Health SciencesRecruiting
- Condition: ParkinsonsIntervention: Radiation: PiB and VATSponsors: Washington University School of Medicine; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA)Recruiting
- Conditions: Alzheimers Disease; Dementia; Alzheimers Disease, FamilialInterventions: Drug: Gantenerumab; Drug: Solanezumab; Drug: Matching Placebo (Gantenerumab); Drug: Matching Placebo (Solanezumab); Drug: E2814; Drug: Lecanemab; Drug: Matching Placebo (E2814)Sponsors: Washington University School of Medicine; Eli Lilly and Company; Hoffmann-La Roche; Alzheimer's Association; National Institute on Aging (NIA); Avid Radiopharmaceuticals; Accelerating Medicines Partnership (AMP); Eisai Inc.; Janssen, LPRecruiting
- Condition: Huntington's DiseaseIntervention: Sponsor: CHDI Foundation, Inc.Recruiting
- Condition: Alzheimer's DiseaseIntervention: Sponsors: Washington University School of Medicine; National Institute on Aging (NIA)Recruiting
For a more comprehensive list of our Alzheimer disease clinical trials, please visit the Knight ADRC website, the Knight ADRC Clinical Trials Unit website and DIAN website.
- Condition: Tuberous Sclerosis ComplexInterventions: Drug: Vigabatrin; Drug: PlaceboSponsors: Martina Bebin; National Institute of Neurological Disorders and Stroke (NINDS)Completed
- Conditions: Primary Ciliary Dyskinesia; Kartagener SyndromeIntervention: Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, CincinnatiRecruiting
- Conditions: Primary Ciliary Dyskinesia; Kartagener Syndrome; Primary Immune DeficiencyIntervention: Sponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, Cincinnati; National Heart, Lung, and Blood Institute (NHLBI)Recruiting
- Conditions: Primary Ciliary Dyskinesia; Primary Immune Deficiency; Kartagener SyndromeInterventions: Diagnostic Test: Genetic Testing for PCD or PID; Other: Unaffected Family Member Genetic TestingSponsors: University of North Carolina, Chapel Hill; Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Colorado; Stanford University; Seattle Children's Hospital; The Hospital for Sick Children; McGill University; Children's Hospital Medical Center, CincinnatiRecruiting
- Conditions: Parkinson Disease; Sleep Disorder; FatigueIntervention: Device: SunRay Light BoxesSponsor: Massachusetts General HospitalActive, not recruiting
- Condition: Parkinson DiseaseIntervention: Behavioral: Physical TherapySponsors: Washington University School of Medicine; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Completed
- Condition: ParkinsonsIntervention: Radiation: PiB and VATSponsors: Washington University School of Medicine; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA)Recruiting
- Condition: Huntington's DiseaseIntervention: Sponsor: CHDI Foundation, Inc.Recruiting
- Condition: Multiple SclerosisIntervention: Diagnostic Test: MRISponsors: The Cleveland Clinic; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS); University of Pennsylvania; Cedars-Sinai Medical CenterActive, not recruiting
- Conditions: Primary Progressive Multiple Sclerosis; Secondary Progressive Multiple SclerosisInterventions: Biological: ATA188; Drug: PlaceboSponsor: Atara BiotherapeuticsActive, not recruiting
- Conditions: Spinal Muscular Atrophy; Neuromuscular Diseases; SMAInterventions: Drug: taldefgrobep alfa; Drug: PlaceboSponsor: Biohaven Pharmaceuticals, Inc.Recruiting
- Condition: Spinal Muscular AtrophyIntervention: Drug: RisdiplamSponsor: Genentech, Inc.Recruiting
- Conditions: Sporadic Inclusion Body Myositis; Inclusion Body MyositisIntervention: Sponsors: University of California, Irvine; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Recruiting
- Conditions: Cubital Tunnel Syndrome; Nerve Compression; Nerve Injury; Ulnar NeuropathiesIntervention: Device: Checkpoint BEST SystemSponsors: Checkpoint Surgical Inc.; Congressionally Directed Medical Research ProgramsRecruiting
- Condition: Muscular Dystrophy, DuchenneIntervention: Genetic: SRP-9001Sponsors: Sarepta Therapeutics, Inc.; Hoffmann-La RocheEnrolling by invitation
- Condition: Neuropathic PainInterventions: Drug: Ondansetron 16 mg with Tariquidar; Drug: Ondansetron 16 mg with PlaceboSponsor: Washington University School of MedicineRecruiting
- Conditions: Cubital Tunnel Syndrome; Peroneal Nerve EntrapmentIntervention: Device: Mechanomyography (MMG)Sponsors: Washington University School of Medicine; Mayo ClinicActive, not recruiting
- Condition: DermatomyositisInterventions: Drug: Lenabasum 20 mg; Drug: Lenabasum 5 mg; Drug: PlaceboSponsor: Corbus Pharmaceuticals Inc.Completed
- Conditions: Amyotrophic Lateral Sclerosis, Familial; Amyotrophic Lateral Sclerosis, SporadicIntervention: Sponsors: Washington University School of Medicine; Massachusetts General HospitalSuspended
- Conditions: Sarcoma; Malignant Peripheral Nerve Sheath TumorsInterventions: Drug: PLX3397; Drug: SirolimusSponsors: Gulam Manji; Daiichi Sankyo, Inc.Recruiting
- Conditions: Spinal Muscular Atrophy; Neuromuscular Diseases; SMAInterventions: Drug: taldefgrobep alfa; Drug: PlaceboSponsor: Biohaven Pharmaceuticals, Inc.Recruiting
- Condition: Spinal Muscular AtrophyIntervention: Drug: RisdiplamSponsor: Genentech, Inc.Recruiting
- Condition: Muscular Dystrophy, DuchenneIntervention: Genetic: SRP-9001Sponsors: Sarepta Therapeutics, Inc.; Hoffmann-La RocheEnrolling by invitation
- Condition: Pompe DiseaseIntervention: Biological: ACTUS-101Sponsor: Asklepios Biopharmaceutical, Inc.Recruiting
- Condition: Sleep ApneaInterventions: Drug: Danavorexton; Drug: PlaceboSponsor: TakedaRecruiting
- Conditions: Parkinson Disease; Sleep Disorder; FatigueIntervention: Device: SunRay Light BoxesSponsor: Massachusetts General HospitalActive, not recruiting
- Conditions: Obstructive Sleep Apnea; TonsillitisInterventions: Drug: Hydromorphone; Drug: FentanylSponsor: Washington University School of MedicineCompleted
- Conditions: Sleep; Sedation ComplicationInterventions: Radiation: MRI; Diagnostic Test: Quantitative Sensory Testing (QST); Diagnostic Test: Home sleep study; Other: Acoustic stimulation (65db) up-slope of EEG with QST; Other: Acoustic stimulation (65db) down-slope of EEG with QST; Other: 0 db with QST; Drug: Dexmedetomidine; Other: Breathe-Squeeze TaskSponsor: Washington University School of MedicineActive, not recruiting
- Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; TIA; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter TrialIntervention: Device: CPAPSponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of CincinnatiRecruiting
- Conditions: Heart Failure; Central Sleep ApneaInterventions: Drug: Oxygen; Other: Room AirSponsors: Brigham and Women's Hospital; Ohio State UniversityTerminated
- Conditions: Heart Failure; Defibrillators, Implantable; Monitoring, Physiologic; Cardiac Resynchronization Therapy; Cardiovascular Disease; Heart DiseaseIntervention: Device: HeartLogic SensorsSponsor: Boston Scientific CorporationCompleted
- Condition: Postoperative DeliriumIntervention: Sponsor: Washington University School of MedicineActive, not recruiting
- Conditions: Mild Cognitive Impairment; Sleep Apnea, ObstructiveIntervention: Device: CPAPSponsors: University of Pennsylvania; National Institute on Aging (NIA)Active, not recruiting
- Conditions: Carotid Atherosclerosis; Asymptomatic Carotid Artery Stenosis; Carotid Artery AtheromaIntervention: Drug: 64Cu-25%-CANF-CombSponsors: Washington University School of Medicine; Cedars-Sinai Medical Center; University of California, Santa Barbara; National Heart, Lung, and Blood Institute (NHLBI)Recruiting
- Conditions: Prevention of Ischemic Stroke; Acute Non-cardioembolic Ischemic Stroke; High-risk Transient Ischemic AttackInterventions: Drug: Asundexian (BAY2433334); Drug: PlaceboSponsor: BayerRecruiting
- Conditions: Intra Cerebral Hemorrhage; ICH – Intracerebral Hemorrhage; ICH; Hemorrhage; Stroke; Clot (Blood); Brain; Clot Blood; Cognitive Decline; Cognitive Impairment; Survivorship; Memory Impairment; Motor ActivityIntervention: Sponsors: Johns Hopkins University; National Institute of Neurological Disorders and Stroke (NINDS)Enrolling by invitation
- Condition: Acute Ischemic StrokeInterventions: Device: transcutaneous auricular vagal nerve stimulation; Device: Sham transcutaneous vagal nerve stimulationSponsor: Washington University School of MedicineRecruiting
- Condition: Sickle Cell DiseaseIntervention: Other: CrizanlizumabSponsors: Andria Ford; Novartis PharmaceuticalsRecruiting
- Conditions: Intracranial Arteriosclerosis; StrokeInterventions: Drug: Ticagrelor + Aspirin; Drug: Rivaroxaban + Aspirin; Drug: Clopidogrel + Aspirin; Other: Risk Factor ManagementSponsors: University of Florida; National Institute of Neurological Disorders and Stroke (NINDS); University of Cincinnati; Medical University of South Carolina; Janssen Scientific Affairs, LLC; AstraZenecaRecruiting
- Conditions: Stroke; Thromboses, Intracranial; Aneurysm, BrainIntervention: Procedure: Stroke/Thrombectomy/Aneurysm-specific surgical proceduresSponsor: Medical University of South CarolinaRecruiting
- Condition: Supratentorial HemorrhageIntervention: Device: Aurora Surgiscope SystemSponsors: Integra LifeSciences Corporation; Icahn School of Medicine at Mount Sinai; Oculus Imaging LLCRecruiting
- Condition: Subdural HematomaInterventions: Procedure: Surgical Management; Device: Surgical Management + Treatment; Other: No Treatment; Device: TreatmentSponsor: Medtronic Neurovascular Clinical AffairsRecruiting
- Conditions: Intracerebral Hemorrhage; Atrial FibrillationInterventions: Drug: Apixaban; Drug: AspirinSponsors: Yale University; National Institute of Neurological Disorders and Stroke (NINDS)Recruiting
- Conditions: Ischemic Stroke; Sleep Apnea; Sleep Apnea, Obstructive; TIA; Stroke; CPAP; Telemedicine; Home Sleep Apnea Test; Randomized Clinical Trial; Multicenter TrialIntervention: Device: CPAPSponsors: University of Michigan; National Institute of Neurological Disorders and Stroke (NINDS); FusionHealth LLC; Medical University of South Carolina; University of CincinnatiRecruiting
- Condition: Acute Ischemic StrokeInterventions: Drug: Argatroban; Drug: Eptifibatide; Drug: PlaceboSponsors: Washington University School of Medicine; National Institute of Neurological Disorders and Stroke (NINDS)Recruiting
- Condition: Cerebral StrokeInterventions: Device: EmboTrap® Revascularization Device; Device: CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration CatheterSponsor: Cerenovus, Part of DePuy Synthes Products, Inc.Recruiting
- Condition: Intracerebral HemorrhageInterventions: Biological: Recombinant Activated Factor VII (rFVIIa); Biological: PlaceboSponsors: Joseph Broderick, MD; Novo Nordisk A/S; National Institute of Neurological Disorders and Stroke (NINDS)Recruiting
- Condition: StrokeInterventions: Drug: Apixaban; Drug: AspirinSponsors: Columbia University; National Institute of Neurological Disorders and Stroke (NINDS); University of Cincinnati; Medical University of South Carolina; Bristol-Myers Squibb; Pfizer; Roche Pharma AG; Weill Medical College of Cornell University; University of WashingtonActive, not recruiting
- Condition: Carotid AtherosclerosisIntervention: Device: Cu[64]-25%-CANF-Comb PET-MRSponsor: Washington University School of MedicineCompleted
- Conditions: Heart Attack; Cardiac Arrest; Congestive Heart Failure; Atrial Fibrillation; Angina; Deep Vein Thrombosis; Pulmonary Embolism; Respiratory Arrest; Respiratory Failure; Pneumonia; Gastrointestinal Bleed; Stomach Ulcer; Delirium; Stroke; Nerve Injury; Surgical Wound InfectionIntervention: Sponsor: Washington University School of MedicineCompleted
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