Fighting to Avoid Her Mother’s Fate, for Her Daughters’ Sake (Links to an external site)

Linde Jacobs stands in a lab wearing a black shirt

Linde Jacobs paced back and forth across her bedroom, eyeing the open laptop on the dresser and willing the doctor to appear. Her husband was dropping off their older daughter at school. Their younger daughter was downstairs, occupied by a screen. Linde wanted to be alone when she learned whether she carried the family curse.

Vagus nerve stimulation relieves severe depression (Links to an external site)

The vagus nerves (orange) run from the brain through the neck to the internal organs. People with severe, treatment-resistant depression who received vagus nerve stimulation therapy showed improvement in depressive symptoms, quality of life, and ability to complete the tasks of daily life, according to a national clinical trial led by researchers at WashU Medicine.

People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial led by Washington University School of Medicine in St. Louis.  The findings are published Dec. 18 in a […]

NIH grant funds study of cerebral small vessel disease (Links to an external site)

Brain scans reveal different patterns of white matter injury, highlighted in various colors, that result from cerebral small vessel disease, the second-leading cause of dementia. The National Institutes of Health have awarded a team of researchers at WashU Medicine a grant to investigate the underlying causes of cerebral small vessel disease.

Researchers at Washington University School of Medicine in St. Louis have been awarded $7.5 million from the National Institutes of Health (NIH) to investigate a form of dementia caused by cerebral small vessel disease, the second-leading cause of dementia after Alzheimer’s disease.

Grant will fund development of vaccines to prevent dementia (Links to an external site)

An illustration of what neuronal networks look like as they degrade. WashU researchers are working to design vaccines that could potentially prevent the buildup of inflammatory protein accumulations in the brain, which is one of the precursors to developing Alzheimer’s disease. (Image: Shutterstock)

Alzheimer’s disease and frontotemporal dementia are devastating disorders that emerge following the buildup of misfolded proteins in the brain. The newest generation of Alzheimer’s therapeutics targets accumulations of the protein amyloid beta with engineered antibodies, but the results have been underwhelming, with some adverse effects, not to mention using engineered antibodies can be prohibitively expensive.

Faculty Profile Miranda Orr

Miranda Orr

Miranda Orr, PhD, associate professor of Neurology, is co-director of the Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center. Orr came to Washington University School of Medicine in St. Louis from Wake Forest University School of Medicine in Winston-Salem, North Carolina, where she was an associate professor in the Section of Gerontology and Geriatric Medicine. […]

WashU Medicine reaches all-time high in NIH funding (Links to an external site)

Person in lab coat uses a pipette and vial.

In a testament to the quality and national competitiveness of biomedical research at Washington University School of Medicine in St. Louis, the school secured $683 million in research funding from the National Institutes of Health (NIH) in federal fiscal year 2024 – a record high for WashU Medicine and an affirmation of its leadership in […]

The potential of psychedelic-assisted therapy (Links to an external site)

Ginger Nicol, MD, an associate professor of psychiatry at WashU Medicine, says that psychedelic drugs hold enormous potential for healing currently untreatable mental disorders, but the only way to transform that potential into reality is through rigorous scientific research. As WashU’s only faculty member authorized to work with Schedule 1 drugs, Nicol is the hub through which all such research at WashU must pass. (Photo: Matt Miller/WashU Medicine)

More than half a century after the U.S. government deemed psychedelic drugs to be of “no medical use,” scientists have begun re-evaluating that dismissive assessment with the tools of modern science. Dozens of clinical trials of psychedelic-assisted therapies for depression, anxiety, post-traumatic stress disorder (PTSD) and other conditions are underway or planned. So far, the results […]

Faculty Spotlight Jeffrey Neil

Jeff Neil, MD, PhD, was born and raised in Cleveland, Ohio. He attended St. Ignatius Jesuit High School; the same high school attended by Mike Noetzel, MD, former Director of Pediatric Neurology at St. Louis Children’s Hospital. Neil and Mike didn’t cross paths at school, as Mike played football and Neil played trombone, though Neil […]

Staff Spotlight Lisa Aten

Lisa Aten started working in the medical field over 30 years ago. She was initially in the retail business and was an area sales manager for Dillards Dept. stores. Even then, she loved working with people and helping them. The retail business demanded a lot of time, and she felt she needed to be home […]