Altered gut bacteria may be early sign of Alzheimer’s disease (Links to an external site)

Alzheimer’s disease causes changes to the brain that begin two decades or more before symptoms appear. A study by researchers at Washington University School of Medicine in St. Louis reveals that the bacteria that live in the gut also change before Alzheimer’s symptoms arise, a discovery that could lead to diagnostics or treatments for Alzheimer’s disease that target the gut microbiome.

­People in the earliest stage of Alzheimer’s disease — after brain changes have begun but before cognitive symptoms become apparent — harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

Publication from Horie, Sato, Ghoshal and Bateman wins ISTAART 2023 Publication of the Year Award

Horie, Sato, Ghoshal, Bateman

An article published in Nature Medicine from neurologists Kanta Horie, PhD, Chihiro Sato, PhD, Nupur Ghoshal, MD, PhD, Randall Bateman, MD, and colleagues has won the International Society to Advance Alzheimer’s Research and Treatment (ISTAART) 2023 Publication of the Year Award. The article is titled, “CSF tau microtubule-binding region identifies pathological changes in primary tauopathies.” […]

Addressing Alzheimer’s disproportionate impact on people of color (Links to an external site)

Dr. Joyce Balls-Berry. Photo by Wiley Price.

The Alzheimer’s Association partnered with Washington University in St. Louis on Thursday, May 4 to explore answers to the question along with other health equity issues related to the disease. The event featured three researchers in St. Louis who aim to improve health equity in research, care, and support.  One of those researchers is Dr. Joyce […]

Living Well: Migraines (Links to an external site)

Rachel Darken, MD, PhD

ST. LOUIS, Mo. (KMOV) – The National Headache Foundation estimates nearly 12% of the population experience migraine headaches. But, many people do not know they suffer from this, therefore, it’s never treated. In today’s Living Well, News 4′s Taylor Holt talks to a doctor about how to know if you have them and how you […]

Donation makes 2023 Cerebral Palsy Family Day possible

Waldy Upchurch plays tennis.

The Department of Neurology’s Cerebral Palsy Center is hosting its inaugural Cerebral Palsy Family Day on June 24, 2023, at the Missouri Botanical Gardens. The event originated when a family previously seen in the Cerebral Palsy (CP) Center provided the center with a generous donation. The donor’s wishes were for caregivers of individuals with CP […]

Butt, de Bruin and Keyrouz recipients of 2023 Dean’s Impact Awards

Omar butt, Gabriela de Bruin, Salah Keyrouz

The Washington University Department of Neurology’s Omar Butt, MD, PhD, Gabriela de Bruin, MD, and Salah Keyrouz, MD, FAHA, were recipients of the 2023 Dean’s Impact Awards for their superior efforts in the face of the COVID-19 pandemic. They demonstrated the highest level of professionalism and delivered exceptional results across the missions of the School […]

Stress increases Alzheimer’s risk in female mice but not males (Links to an external site)

Stress causes the levels of Alzheimer's proteins to rise in females' brains but not males' brains, according to a new study in mice by researchers at Washington University School of Medicine in St. Louis. This difference may contribute to women's greater risk of developing Alzheimer's disease.

Women are about twice as likely as men to be diagnosed with Alzheimer’s disease. Some of that is age; in the U.S., women outlive men by five to six years, and advanced age is the strongest risk factor for Alzheimer’s. But there’s more to it than that, so Alzheimer’s researchers continue to look for other […]

Alicia Vonderheid announced as Department of Neurology’s Staff Employee of the Quarter

Ali Vonderheid

The Department of Neurology congratulates Neurology Clinical Research Coordinator II Alicia Vonderheid for being awarded the Neurology Staff Employee of the Quarter for Q3 FY23. Vonderheid was nominated by faculty and staff because of her exceptional ability to make research participants and their caretakers feel calm and cared for. Those who nominated her, also, highlighted […]

Drug for rare form of ALS, based in part on WashU research, approved by FDA (Links to an external site)

A new drug has been approved by the Food and Drug Administration (FDA) for a rare, inherited form of amyotrophic lateral sclerosis (ALS). Called tofersen, the drug — developed by Biogen Inc. and based in part on research conducted at Washington University School of Medicine in St. Louis — slows the progression of the deadly, paralyzing disease.

A new drug has been approved by the Food and Drug Administration (FDA) for a rare, inherited form of amyotrophic lateral sclerosis (ALS), a paralyzing neurological disease. Known as tofersen, the drug has been shown to slow progression of the deadly disease. International clinical trials of tofersen, developed by the global biotechnology company Biogen Inc., […]