Neurophysiology
Cirrito Lab
John Cirrito, PhD
The Cirrito lab focuses on understanding the metabolism Abeta within the brain extracellular fluid or interstitial fluid (ISF). It developed a novel in vivo microdialysis technique that enables us to specifically measure ISF Abeta within the brains of living and awake wildtype and APP transgenic mice.
Dosenbach Lab
Nico U.F. Dosenbach, MD, PhD
Plasticity is one of the hallmark features of the human brain. Use-driven plasticity is critically important for typical development as well as recovering from brain injury. Thus, the overarching goal of our research is to better understand use-driven brain plasticity.
Geisler Lab
Stefanie Geisler, MD
The goal of the Geisler lab is to identify new therapeutic agents that can be translated into relevant treatment strategies for patients suffering from peripheral neuropathies. We integrate genetic data from patients and analysis of patient-derived neurons with information from cell and animal models to gain insight into molecular mechanisms underlying axon degeneration and regeneration.
Hyrc Lab
Krzysztof Hyrc, PhD
Krzysztof Hyrc, PhD, is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.
Thio Lab
Kwee Liu Lin Thio, MD, PhD
The research interests of Liu-Lin Thio, MD, PhD, are cellular neurophysiology, inhibitory glycine receptors and ketogenic diet. He holds clinic weekly, is consultant pediatric epileptologist for the Pediatric Cerebral Palsy Center and serves on the Pharmaceutical, Diagnostics and Therapeutics Subcommittee at St. Louis Children’s Hospital.