Dosenbach Lab
Nico U.F. Dosenbach, MD, PhD
The intricate complexity of the human brain drives our research group’s quest for understanding through numerous advanced methods. To overcome the challenges of studying brain organization and function, we have created a multi-faceted plan of attack. One significant approach is precision functional mapping (PFM), where we collect high-quality MRI data from individual brains to create precise functional network maps, revealing unique insights like the somato-cognitive action network. Another method is brain-wide association studies (BWAS), which use large consortium data sets to find associations between brain structure/function and cognitive or psychiatric factors, offering population-level insights.
Additionally, precision imaging drug trials (PIDT) facilitate the study of medication effects on the brain, enhancing our understanding of psychoactive substances at an individual level. We also investigate behavioral plasticity through interventions like constraint-induced movement therapy, and explore perinatal stroke survivors as models of successful neuroplasticity. Our development of real-time methods like the framewise tntegrated real-time MRI monitoring (FIRMM) software combats MRI quality issues caused by head movement. Finally, the use of deep phenotyping through wearable biosensors allows for more accurate tracking of behaviors and neuropsychological data. All these efforts focus on acquiring better, more individualized, and population-level data to advance our understanding of brain plasticity and improve MRI data quality and diagnostic capabilities.
Principal investigator
Our team
Recent publications
- Psilocybin’s acute and persistent brain effects: a precision imaging drug trialSubramanian, S., Renau, T. R., Perry, D., Chacko, R., Laumann, T. O., Flavin, K., Horan, C., Schweiger, J., Metcalf, N., Lenze, E. J., Snyder, A. Z., Dosenbach, N. U. F., Nicol, G. & Siegel, J. S., Dec 2025, In: Scientific data. 12, 1, 941.Research output: Contribution to journal › Article › peer-review
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulationJi, G. J., Fox, M. D., Morton-Dutton, M., Wang, Y., Sun, J., Hu, P., Chen, X., Jiang, Y., Zhu, C., Tian, Y., Zhang, Z., Akkad, H., Nordberg, J., Joutsa, J., Torres Diaz, C. V., Groppa, S., Gonzalez-Escamilla, G., Toledo, M. D., Dalic, L. J. & Archer, J. S. & 24 others, Selway, R., Stavropoulos, I., Valentin, A., Yang, J., Isbaine, F., Gross, R. E., Park, S., Gregg, N. M., Cukiert, A., Middlebrooks, E. H., Dosenbach, N. U. F., Turner, J., Warren, A. E. L., Chua, M. M. J., Cohen, […]
- Disuse-driven plasticity in the human thalamus and putamenChauvin, R. J., Newbold, D. J., Nielsen, A. N., Miller, R. L., Krimmel, S. R., Metoki, A., Wang, A., Van, A. N., Montez, D. F., Marek, S., Suljic, V., Baden, N. J., Ramirez-Perez, N., Scheidter, K. M., Monk, J. S., Whiting, F. I., Adeyemo, B., Roland, J. L., Snyder, A. Z. & Kay, B. & 4 others, Raichle, M. E., Laumann, T. O., Gordon, E. & Dosenbach, N. U. F., Apr 22 2025, In: Cell Reports. 44, 4, 115570.Research output: Contribution to journal › Article › peer-review
- The brain’s action-mode networkDosenbach, N. U. F., Raichle, M. E. & Gordon, E. M., Mar 2025, In: Nature Reviews Neuroscience. 26, 3, p. 158-168 11 p., 3569.Research output: Contribution to journal › Article › peer-review
- Engaging dystonia networks with subthalamic stimulationButenko, K., Neudorfer, C., Dembek, T. A., Hollunder, B., Meyer, G. M., Li, N., Oxenford, S., Bahners, B. H., Al-Fatly, B., Lofredi, R., Gordon, E. M., Dosenbach, N. U. F., Ganos, C., Hallett, M., Jinnah, H. A., Starr, P. A., Ostrem, J. L., Wu, Y., Zhang, C. C. & Fox, M. D. & 1 others, Horn, A., Jan 14 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 2, e2417617122.Research output: Contribution to journal › Article › peer-review