Neuroimmunology
Brier Lab
Matthew R. Brier, MD, PhD
The Brier lab uses neuroimaging to study multiple sclerosis (MS). Advances in disease modifying therapies allow for the reduction of inflammatory relapses in patients with MS. However, despite these incredible treatments, many patients still experience progressive disability accumulation associated with neurodegeneration. We are principally interested in how this progressive degenerative pathology emerges in the context of seemingly well treated relapsing MS.
Li Lab
Mingjie Li, MD, PhD
The Li lab is developing new vectors for neurological applications. The goal of the Viral Vectors Core is to assist Washington University neuroscience researchers in the design and production of various kinds of vectors.
Saligrama Lab
Naresha Saligrama, PhD
The focus of the Saligrama lab is on T cell repertoire in autoimmunity, T cell specificity and function in autoimmunity and systems analysis of immune system in neurological disorders.
Wu Lab
Gregory Wu, MD, PhD
The main goal of our research is to define the regulation of adaptive immune responses during inflammation within the central nervous system (CNS). The Wu lab has several areas of ongoing investigation into the pathogenesis of multiple sclerosis (MS) and related diseases. We are exploring characteristics of monocytes, microglia and B cells from patients to better understand cell-intrinsic abnormalities underpinning neuroimmunologic dysregulation in human diseases.