Matthew R. Brier, MD, PhD
The Brier lab uses neuroimaging to study multiple sclerosis (MS). Advances in disease modifying therapies allow for the reduction of inflammatory relapses in patients with MS. However, despite these incredible treatments, many patients still experience progressive disability accumulation associated with neurodegeneration. We are principally interested in how this progressive degenerative pathology emerges in the context of seemingly well treated relapsing MS.
Anne Cross, MD
The goal of the Cross lab's research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (brain and spinal cord).
Mingjie Li, MD, PhD
The Li lab is developing new vectors for neurological applications. The goal of the Viral Vectors Core is to assist Washington University neuroscience researchers in the design and production of various kinds of vectors.
Robert T. Naismith, MD
Robert T. Naismith, MD, is interested in improving the use of imaging modalities to better prognosticate and care for those with multiple sclerosis. The current focus is on MR Diffusion Tensor Imaging as a pathologic surrogate for axonal loss. This includes studies in the optic nerves, brain and spinal. The studies include measurements and outcomes that are important to patients and have relevance for implementing in clinical practice.
Naresha Saligrama, PhD
The focus of the Saligrama lab is on T cell repertoire in autoimmunity, T cell specificity and function in autoimmunity and systems analysis of immune system in neurological disorders.
Gregory Wu, MD, PhD
The main goal of the Wu lab's research is to define the antigen presentation requirements during inflammation within the central nervous system (CNS). Several different antigen-presenting cells (APCs) participate in CD4 T cell-mediated immunity.