A drug under consideration by the Food and Drug Administration for multiple sclerosis has shown superiority in terms of gastrointestinal tolerability over its comparator. But while analysts said the drug will likely win FDA approval, it is uncertain if the latest data will drive significant uptake, especially with the comparator’s anticipated availability as a generic.
ST. LOUIS, Missouri – Amy Thomas was diagnosed with Multiple Sclerosis 13 years ago. “It’s just another component of my life to manage. It’s not defining who I am.” She regularly gets blood drawn to measure the benefits of intermittent fasting. In a study measuring the benefits of intermittent fasting, she eats non-starchy vegetables two days a week. […]
Washington University School of Medicine in St. Louis has received a $15 million gift from Paula and Rodger Riney aimed at accelerating research and developing new treatments for two major neurodegenerative diseases: Alzheimer’s disease and Parkinson’s disease. Of the gift, $10 million will support Alzheimer’s disease research, while $5 million will support studies of Parkinson’s […]
Joel S. Perlmutter, MD, the Elliot H. Stein Family Professor of Neurology at Washington University School of Medicine in St. Louis, has been named scientific director of the Dystonia Medical Research Foundation. Dystonia is a neurological disorder that causes excessive, involuntary muscle contractions and abnormal postures.
Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, has been awarded the Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases. He will receive the award May 6 at the American Academy of Neurology’s annual meeting in Philadelphia.
Brains do a lot of work while we sleep—far from being a passive behavior, sleep is actually critical to brain health, and as a result, mental and cognitive health. A few new studies in recent weeks underline how important sleep is, and how detrimental lack of sleep can be. And not just chronic lack of […]
Poor sleep has long been linked with Alzheimer’s disease, but researchers have understood little about how sleep disruptions drive the disease. Now, studying mice and people, researchers at Washington University School of Medicine in St. Louis have found that sleep deprivation increases levels of the key Alzheimer’s protein tau. And, in follow-up studies in the […]
Poor sleep is a hallmark of Alzheimer’s disease. People with the disease tend to wake up tired, and their nights become even less refreshing as memory loss and other symptoms worsen. But how and why restless nights are linked to Alzheimer’s disease is not fully understood.
Mice that sleep fitfully could help researchers unravel the mystery of insomnia. Researchers at Washington University School of Medicine in St. Louis studied mice genetically modified to mimic the genetic disease neurofibromatosis type 1 (NF1), which is associated with sleep problems. They found that the animals, like some people with NF1, slept in short, irregular […]
Scientists have found a biological clue that could help explain why African-Americans appear to be more vulnerable than white Americans to Alzheimer’s disease. A study of 1,255 people, both black and white, found that cerebrospinal fluid from African-Americans tended to contain lower levels of a substance associated with Alzheimer’s, researchers report Monday in the journal JAMA Neurology.