Metabolic disturbance in the brain exacerbates, may forewarn Alzheimer’s pathology (Links to an external site)

CHICAGO — A better understanding of the metabolic processes in the brain — specifically disturbances resulting from neurodegenerative diseases — has important implications for potential treatments. The research was presented at Neuroscience 2019, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health.

Holtzman awarded Watanabe Prize in Translational Research (Links to an external site)

Holtzman

David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology at Washington University School of Medicine in St. Louis, has received the August M. Watanabe Prize in Translational Research from the Indiana Clinical and Translational Sciences Institute. He was recognized for his work uncovering the causes of Alzheimer’s disease […]

Gutmann to be fellow at Berlin Institute of Health (Links to an external site)

Gutmann

David Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology at the School of Medicine, has received a second Einstein Visiting Fellowship from the Berlin Institute of Health to study how immune cells in the brain known as microglia are linked to cancer, vision loss and behavioral problems in the disease neurofibromatosis type 1.

Alzheimer’s research reset (Links to an external site)

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After some costly and disappointing drug trial failures, the field welcomes a funding surge, tools for tracking disease, and interdisciplinary collaborations to tackle one of science’s most stubborn puzzles. In the last five years, as several large clinical trials testing drugs for Alzheimer’s disease failed, the field came to a stark conclusion: These approaches did […]

Genes linked to Alzheimer’s risk, resilience ID’d (Links to an external site)

A team led by researchers at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for Alzheimer’s disease. The genes — known as MS4A4A and TREM2 — affect the brain’s immune cells. They influence Alzheimer’s risk by altering levels of TREM2, a protein (shown stained in red) that is believed to help microglia cells clear excessive amounts of the Alzheimer’s proteins amyloid and tau from the brain. The MS4A4A protein is shown stained in green. (Image: Fabia Filipello and Dennis Oakley)

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer’s disease. Most genes implicated thus far in Alzheimer’s affect neurons that transmit messages, allowing different regions of the brain to communicate with one […]

Cross honored for multiple sclerosis research (Links to an external site)

Anne H. Cross, MD, the Manny and Rosalyn Rosenthal and Dr. John L. Trotter MS Center Chair in Neuroimmunology at Washington University School of Medicine in St. Louis, has received the John Dystel Prize for Multiple Sclerosis Research from the National Multiple Sclerosis Society and the American Academy of Neurology. The award recognizes outstanding contributions […]