Zempel Lab

John Zempel, MD, PhD

As a pediatric epileptologist, the goal of the Zempel lab’s research is to improve the localization of neuronal activity through new imaging modalities that are translatable to humans. By studying a model system of partial seizures which has been adapted to the magnetic resonance environment, allowing the measurement of electrical signals concurrent with imaging. Using conventional and newly developed magnetic resonance techniques, Zempel and his colleagues have localized ongoing seizure activity and characterized the damage that occurs with seizures. He is also characterizing and utilizing new magnetic resonance contrast agents with the goal of using such an agent to localize seizure activity to provide a major advance in the diagnosis and treatment of epilepsy.

A second focus of Zempel’s research is the quantitative characterization of electrical activity directly recorded from the human brain as part of an evaluation for epilepsy surgery. The ready availability of increasing computational power makes analysis of the characteristics of brain activity feasible in the time frame of the surgery evaluation. Such techniques focus on seizure detection, prediction and characterization of the zone of abnormal brain tissue.

Principal investigator

John Zempel, MD, PhD

John Zempel, MD, PhD

Professor of Neurology
Pediatric Epilepsy
Director, EEG Laboratories, St. Louis Children’s Hospital


  Zempel lab

 
Top areas of pediatric care: autism, EEG, Landau-Kleffner syndrome

Research profile
Clinical profile

Recent publications

  • Safety and accuracy of stereoelectroencephalography for pediatric and young adult patients with prior craniotomy
    Safety and accuracy of stereoelectroencephalography for pediatric and young adult patients with prior craniotomyYang, P. H., Wulfekammer, N., Jenson, A. V., Neal, E. G., Tomko, S., Zempel, J., Brunner, P., McEvoy, S. D., Smyth, M. D. & Roland, J. L., Nov 2024, In: Journal of Neurosurgery: Pediatrics. 34, 5, p. 526-536 11 p.Research output: Contribution to journal › Article › peer-review
  • Multi-site EEG studies in early infancy: Methods to enhance data quality
    Multi-site EEG studies in early infancy: Methods to enhance data qualityfor the IBIS Network, Oct 2024, In: Developmental Cognitive Neuroscience. 69, 101425.Research output: Contribution to journal › Article › peer-review
  • FDG-PET/MRI in the presurgical evaluation of pediatric epilepsy
    FDG-PET/MRI in the presurgical evaluation of pediatric epilepsyPonisio, M. R., Zempel, J. M., Willie, J. T., Tomko, S. R., McEvoy, S. D., Roland, J. L. & Williams, J. P., Sep 2024, In: Pediatric radiology. 54, 10, p. 1589-1602 14 p.Research output: Contribution to journal › Review article › peer-review
  • An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal Syndrome
    An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal SyndromeLust, C., Vesoulis, Z., Zempel, J., Gu, H., Lee, S., Rao, R. & Mathur, A. M., May 14 2024, In: American journal of perinatology. 41, p. E290-E297Research output: Contribution to journal › Article › peer-review
  • Macroperiodic Oscillations: A Potential Novel Biomarker of Outcome in Neonatal Encephalopathy
    Macroperiodic Oscillations: A Potential Novel Biomarker of Outcome in Neonatal EncephalopathyKeene, J. C., Loe, M. E., Fulton, T., Keene, M., Mathur, A., Morrissey, M. J., Tomko, S. R., Vesoulis, Z. A., Zempel, J. M., Ching, S. & Guerriero, R. M., May 1 2024, In: Journal of Clinical Neurophysiology. 41, 4, p. 344-350 7 p.Research output: Contribution to journal › Article › peer-review
Complete bibliography