Neurodegeneration
Ju Lab
Yo-El Ju, MD, MSCI
The Ju lab studies the relationship between sleep and neurodegenerative diseases through translational and clinical research.
Kotzbauer Lab
Paul Kotzbauer, MD, PhD
The Kotzbauer lab is working to understand mechanisms of neurodegeneration underlying Parkinson’s disease and related disorders. Specific types of pathological neuronal inclusions that occur in Parkinson’s disease also occur in other neurodegenerative diseases, suggesting that common mechanisms of pathogenesis may be involved.
Kress Lab
Geraldine Kress, PhD
My research interests focus on understanding interactions between cognitive function and the circadian system during the aging process and Alzheimer’s disease (AD) progression in order to identify pathophysiology changes, mechanisms, and possible strategies to ameliorate disease progression.
Kummer Lab
Terrance T. Kummer, MD, PhD
Research at the Kummer lab and in our collaborative group is focused on the mechanisms of cellular damage in traumatic brain injury (TBI) and in Alzheimer’s disease, with a particular focus on synaptic and other forms of gray matter injury. TBI is a major cause of morbidity and mortality in the U.S. and worldwide and a major risk factor for the development of Alzheimer’s disease.
Lee Lab
Jin-Moo Lee, MD, PhD
Alzheimer’s disease (AD) is associated with the accumulation of aggregated amyloid-beta peptide (Abeta) in senile plaques within the brain.
Lucey Lab
Brendan P. Lucey, MD, MSCI, FAASM
The Lucey lab investigates the relationship between sleep, aging and Alzheimer’s disease. Recent evidence suggests a role for sleep in Alzheimer’s disease pathogenesis and/or as a marker for the onset and/or progression of Alzheimer’s disease that could be followed as an outcome measure in treatment trials. The major goal of our research is use sleep to prevent or delay Alzheimer’s disease.
Miller Lab
Timothy Miller, MD, PhD
The Miller lab is dedicated to understanding neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and dementias in order to develop new, effective and safe treatments. Part of the Department of Neurology at Washington University School of Medicine in St. Louis, the Miller lab is headed by Timothy M. Miller, MD, PhD, the David Clayson Professor of Neurology. Miller is a national leader in translational neuroscience and new therapeutic approaches for neurodegenerative diseases.
Morris Lab
John Carl Morris, MD
The focus of John Morris’ research and practice is Alzheimer’s disease and other neurological disorders associated with aging.
Musiek Lab
Erik S. Musiek, MD, PhD
The Musiek lab studies how circadian rhythms and the circadian clock system influence neurodegenerative diseases, in particular Alzheimer’s disease. Research focuses on the molecular mechanisms by which the circadian clock regulates processes such as inflammation, oxidative stress and protein aggregation in cellular and animal models of Alzhiemer’s disease and other age-related neurodegenerative conditions.
Perlmutter Lab
Joel S. Perlmutter, MD
Joel Perlmutter’s main research interests include neuroimaging, basal ganglia physiology and pharmacology, mechanisms of deep-brain stimulation, pathophysiology of dystonia, development of new agents to reduce nigrostriatal injury and electronic medical records systems.