Morris Lab

John Carl Morris, MD

The focus of John Morris’ research and practice is Alzheimer’s disease and other neurological disorders associated with aging. Specific research interests include improving the diagnosis of early-stage Alzheimer’s disease, clinicopathological correlations in dementing disorders, evaluating new drugs for the treatment of dementia, establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias and identifying preclinical stages of Alzheimer’s disease by biomarker and neuroimaging studies.

Principal investigator

John  Morris, MD

John Morris, MD

Harvey A. & Dorismae Hacker Friedman Professor of Neurology
Director, Aging & Dementia
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project

  Morris lab

Top areas of adult care: Alzheimer’s disease, dementia, geriatric neurology

Recent publications

  • Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s diseaseDominantly Inherited Alzheimer Network (DIAN) Consortia, Dec 2023, In: npj Parkinson's Disease. 9, 1, 107.Research output: Contribution to journal › Article › peer-review
  • Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer diseaseKnight Alzheimer Disease Research Center (Knight ADRC), the Dominantly Inherited Alzheimer Network (DIAN), Alzheimer’s Disease Neuroimaging Initiative (ADNI), ADNI-DOD, A4 Study Team, the Australian Imaging Biomarkers, Lifestyle (AIBL) Study, Ali, M., Archer, D. B., Gorijala, P., Western, D., Timsina, J., Fernández, M. V., Chen, G., Gordon, B., Benzinger, T. L. S., Xiong, C., Morris, J. C., Bateman, R. J., Karch, C. M., McDade, E., Sung, Y. J., & 1 othersCruchaga, C., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 68.Research output: Contribution to journal › Article › peer-review
  • Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriersDominantly Inherited Alzheimer Network (DIAN), Brase, L., You, S. F., D’Oliveira Albanus, R., Novotny, B. C., Soriano-Tarraga, C., Dykstra, T., Fernandez, M. V., Budde, J. P., Bergmann, K., Morris, J. C., Bateman, R. J., Perrin, R. J., McDade, E., Xiong, C., Kipnis, J., Karch, C. M., Benitez, B. A. & Harari, O., Dec 2023, In: Nature communications. 14, 1, 2314.Research output: Contribution to journal › Article › peer-review
  • Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer’s diseasefor the PREVENT-AD Research Group & Morris, J. C., Dec 2023, In: Scientific reports. 13, 1, 7487.Research output: Contribution to journal › Article › peer-review
  • Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individualsPettigrew, C., Nazarovs, J., Soldan, A., Singh, V., Wang, J., Hohman, T., Dumitrescu, L., Libby, J., Kunkle, B., Gross, A. L., Johnson, S., Lu, Q., Engelman, C., Masters, C. L., Maruff, P., Laws, S. M., Morris, J. C., Hassenstab, J., Cruchaga, C., Resnick, S. M., & 3 othersKitner-Triolo, M. H., An, Y. & Albert, M., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 66.Research output: Contribution to journal › Article › peer-review