Morris Lab
John Carl Morris, MD
John Morris focuses his research and clinical work on Alzheimer’s disease and other age-related neurological disorders. His key areas of interest include:
- Identifying preclinical stages of Alzheimer’s using biomarkers and neuroimaging
- Improving early diagnosis of Alzheimer’s disease
- Studying the relationship between clinical symptoms and brain pathology in dementia
- Testing new drugs for treating dementia
- Defining genetic forms of Alzheimer’s and other dementias
Principal investigator
Recent publications
- Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementiathe Alzheimer's Disease Neuroimaging Initiative, Dec 2026, In: Nature communications. 17, 1, 4152.Research output: Contribution to journal › Article › peer-review
- Genetic modifiers of APOE-ε4-associated cognitive declineThe Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Genetics Consortium (ADGC) & The Alzheimer's Disease Sequencing Project (ADSP), Dec 2026, In: Nature communications. 17, 1, 2982.Research output: Contribution to journal › Article › peer-review
- Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer diseaseTarawneh, R., Moulder, K. L., Topouza, D. G., Kar, A., Qian, H. T., Pankratz, V. S., Timsina, J., Franklin, E. E., Schindler, S. E., Perrin, R. J., Ances, B. M., Benzinger, T. L. S., Hassenstab, J., Morris, J. C., Holtzman, D. M. & Cruchaga, C., Dec 2026, In: Alzheimer's Research and Therapy. 18, 1, 152.Research output: Contribution to journal › Article › peer-review
- GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagyTimsina, J., Jiang, C., McCartney, D. L., Tao, F., Dalmasso, M. C., Najar, J., Anastasi, F., Ohlei, O., Puerta Fuentes, R., Yang, C., Bradley, J., Western, D., Ali, M., Wang, C., Yang, C., Wu, Y., Liu, M., Budde, J., Williams, J. & Mahoney, R. & 135 others, Castillo Morales, A., Hohman, T. J., Dumitrescu, L., Wang, T. C., Tesi, N., Kern, S., Waern, M., Skoog, I., van Harten, A., Pijnenburg, Y. A. L., van der Flier, W. M., Sánchez-Juan, P., Rodriguez-Rodriguez, E., Kleineidam, L., Peters, O., […]
- Sample size determination for a prospective bridging study to harmonize retrospective data from multiple studies—Application to a biofluid biomarker study of Alzheimer’s diseaseXiong, C., Nie, Y., Luo, J., Lu, R., Wolk, D., Shaw, L. M., Gleason, C. E., Johnson, S. C., Agboola, F., Morris, J. & Schindler, S., Oct 2026, In: Statistical Methods in Medical Research. 35, 10, p. 2047-2060 14 p.Research output: Contribution to journal › Article › peer-review