Morris Lab

John Carl Morris, MD

The focus of John Morris’ research and practice is Alzheimer’s disease and other neurological disorders associated with aging. Specific research interests include improving the diagnosis of early-stage Alzheimer’s disease, clinicopathological correlations in dementing disorders, evaluating new drugs for the treatment of dementia, establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias and identifying preclinical stages of Alzheimer’s disease by biomarker and neuroimaging studies.

Principal investigator

John  Morris, MD

John Morris, MD

Harvey A. & Dorismae Hacker Friedman Professor of Neurology
Director, Section of Aging & Dementia
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project

  Morris lab

Top areas of adult care: Alzheimer’s disease, dementia, geriatric neurology

Recent publications

  • Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clusteringYang, Z., Wen, J., Abdulkadir, A., Cui, Y., Erus, G., Mamourian, E., Melhem, R., Srinivasan, D., Govindarajan, S. T., Chen, J., Habes, M., Masters, C. L., Maruff, P., Fripp, J., Ferrucci, L., Albert, M. S., Johnson, S. C., Morris, J. C., LaMontagne, P., Marcus, D. S., & 8 othersBenzinger, T. L. S., Wolk, D. A., Shen, L., Bao, J., Resnick, S. M., Shou, H., Nasrallah, I. M. & Davatzikos, C., Dec 2024, In: Nature communications. 15, 1, 354.Research output: Contribution to journal › Article › peer-review
  • Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's diseaseWelhaf, M. S., Wilks, H., Aschenbrenner, A. J., Balota, D. A., Schindler, S. E., Benzinger, T. L. S., Gordon, B. A., Cruchaga, C., Xiong, C., Morris, J. C. & Hassenstab, J., Jun 29 2024, In: Journal of the International Neuropsychological Society. 30, 5, p. 428-438 11 p.Research output: Contribution to journal › Article › peer-review
  • Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom OnsetLi, Y., Yen, D., Hendrix, R. D., Gordon, B. A., Dlamini, S., Barthélemy, N. R., Aschenbrenner, A. J., Henson, R. L., Herries, E. M., Volluz, K., Kirmess, K., Eastwood, S., Meyer, M., Heller, M., Jarrett, L., McDade, E., Holtzman, D. M., Benzinger, T. L. S., Morris, J. C., Bateman, R. J., & 2 othersXiong, C. & Schindler, S. E., May 2024, In: Annals of neurology. 95, 5, p. 951-965 15 p.Research output: Contribution to journal › Article › peer-review
  • Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid testsBarthélemy, N. R., Salvadó, G., Schindler, S. E., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J., & 1 othersHansson, O., Apr 2024, In: Nature medicine. 30, 4, p. 1085-1095 11 p.Research output: Contribution to journal › Article › peer-review
  • Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s diseaseEteleeb, A. M., Novotny, B. C., Tarraga, C. S., Sohn, C., Dhungel, E., Brase, L., Nallapu, A., Buss, J., Farias, F., Bergmann, K., Bradley, J., Norton, J., Gentsch, J., Wang, F., Davis, A. A., Morris, J., Karch, C. M., Perrin, R. J., Benitez, B. A. & Harari, O., Apr 2024, In: PLoS biology. 22, 4 April, e3002607.Research output: Contribution to journal › Article › peer-review