Adult research labs
Musiek Lab
Erik S. Musiek, MD, PhD
Studies how circadian rhythms influence neurodegenerative diseases like Alzheimer’s. By examining molecular mechanisms that regulate inflammation, oxidative stress and protein aggregation, the lab aims to uncover how the circadian clock impacts brain health and identify new therapeutic targets.
Naismith Lab
Robert T. Naismith, MD
Focused on improving care for people with multiple sclerosis through advanced imaging techniques. By using MR Diffusion Tensor Imaging to study axonal loss in the brain, spinal cord and optic nerves, the lab aims to develop clinically relevant tools that enhance diagnosis and treatment.
Perlmutter Lab
Joel S. Perlmutter, MD
Investigating movement disorders like Parkinson’s disease and dystonia. Through neuroimaging, deep brain stimulation studies and translational research, the lab explores brain physiology, develops biomarkers and tests therapies to improve diagnosis, treatment and understanding of these conditions.
Pestronk Lab
Alan Pestronk, MD
Focused on neuromuscular disorders through clinical and research efforts. The lab investigates conditions like myopathy, neuropathy and myasthenia gravis, emphasizing neuroimmunology, aging and molecular mechanisms to improve diagnosis and treatment.
Pottier Lab
Cyril P. Pottier, PhD
Investigating genetic drivers and biomarkers of early-onset dementias, including young-onset Alzheimer’s disease and frontotemporal dementia, using multi-omics approaches to uncover therapeutic targets and modifiers.
Saligrama Lab
Naresha Saligrama, PhD
Studing adaptive immune responses in neurological health and disease. By using high-throughput sequencing and bioinformatics, the lab investigates T cell receptor diversity and antigen specificity to better understand neuroinflammatory, neurodegenerative and neuropsychiatric disorders.
Struck Lab
Aaron Struck, MD
Harnessing cutting-edge imaging and AI technologies, our lab is dedicated to advancing epilepsy research with a focus on refractory cases. By integrating neuroimaging modalities such as MRI, PET and EEG with machine learning approaches, we aim to uncover the underlying mechanisms of treatment-resistant epilepsy. Our ultimate goal is to improve patient outcomes by identifying predictive neurological markers and enhancing clinical care through data-driven insights.
Weihl Lab
Conrad Weihl, MD, PhD
Investigating how disruptions in protein quality control contribute to muscle and neurodegenerative diseases. Using biochemistry, cell culture, animal models and patient tissue, the lab studies conditions like inclusion body myopathy, Paget’s disease, frontotemporal dementia and limb-girdle muscular dystrophy to uncover mechanisms of protein aggregation and cellular degeneration. [weihllab.wustl.edu]
Wu Lab
Gregory Wu, MD, PhD
Investigates how adaptive immune responses are regulated during central nervous system inflammation. By studying monocytes, microglia and B cells in patients with multiple sclerosis and related diseases, the lab aims to uncover immune mechanisms and develop more effective therapies through clinical trials and experimental models.
Zhao Lab
Guoyan Zhao, PhD
Department of Genetics
Exploring transcriptional regulation in the nervous system using computational and experimental methods to understand mechanisms behind chronic pain and neurodegenerative diseases such as Alzheimer, Parkinson and Lewy body disorders.