Wu Lab

The main goal of our research is to understand how adaptive immune responses are regulated during inflammation in the central nervous system (CNS). The Wu Lab investigates the pathogenesis of multiple sclerosis (MS) and related neuroimmunologic diseases through several ongoing projects.

Cellular mechanisms in human disease
We study monocytes, microglia, and B cells from patients to uncover cell-intrinsic abnormalities that contribute to immune dysregulation in neuroinflammatory conditions.

Experimental models of neuroinflammation
Using various experimental autoimmune encephalomyelitis (EAE) systems, we model the cellular and molecular immune contributions to neuroinflammation. These models help us dissect the mechanisms driving CNS pathology.

Clinical trials and therapeutic development
We are actively involved in clinical trials aimed at identifying highly effective disease-modifying therapies for MS. We also investigate the mechanisms of action behind currently approved treatments to improve therapeutic strategies.

Principal investigator

Our team

Recent publications

• A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
  January 2, 2025
  A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populationsCantoni, C., Smirnov, R. A., Firulyova, M., Andhey, P. S., Bradstreet, T. R., Esaulova, E., Terekhova, M., Schwarzkopf, E. A., Abdalla, N. M., Kleverov, M., Sabatino, J. J., Liu, K., Schwab, N., Meyer Zu Hörste, G., Cross, A. H., Artyomov, M. N., Edelson, B. T. & Wu, G. F., Jan 2 2025, In: Journal of Clinical Investigation. 135, 1, e177793.Research output: Contribution to journal › Article › peer-review
• Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis
  August 20, 2024
  Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosisGhezzi, L., Tosti, V., Shi, L., Cantoni, C., Mikesell, R., Lancia, S., Zhou, Y., Obert, K., Dula, C., Sen, M. K., Ge, A., Tolentino, M., Bollman, B., Don, A. S., Matarese, G., Colamatteo, A., La Rocca, C., Lepore, M. T., Raji, C. A. & Rahmani, F. & 6 others, Wu, G. F., Naismith, R. T., Fontana, L., Cross, A. H., Salter, A. & Piccio, L., Aug 20 2024, In: Journal of Neurology, Neurosurgery and Psychiatry. 96, 2Research output: Contribution to journal › Article › peer-review
• Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restriction
  August 1, 2024
  Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restrictionMartin, K., Cofield, S. S., Cross, A. H., Goss, A. M., Raji, C. A., Rinker, J. R., Wu, G. F., Blair, J., Fuchs, A., Ghezzi, L., Green, K., Pace, F., Pastori, G., Taylor, M. G., Piccio, L. & Wingo, B. C., Aug 2024, In: Contemporary Clinical Trials. 143, 107584.Research output: Contribution to journal › Article › peer-review
• Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseases
  June 15, 2024
  Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseasesTrivedi, R. R., Archambault, A. S., Pavlak, C., Gastaldi, M., Cantoni, C., Ghezzi, L., Cross, A. H., Miller, T. M. & Wu, G. F., Jun 15 2024, In: Journal of the Neurological Sciences. 461, 123041.Research output: Contribution to journal › Article › peer-review
• Sex differences in plasma proteomic markers in late-life depression
  April 1, 2024
  Sex differences in plasma proteomic markers in late-life depressionXue, X., Demirci, D., Lenze, E. J., Reynolds III, C. F., Mulsant, B. H., Wetherell, J. L., Wu, G. F., Blumberger, D. M., Karp, J. F., Butters, M. A., Mendes-Silva, A. P., Vieira, E. L., Tseng, G. & Diniz, B. S., Apr 2024, In: Psychiatry Research. 334, 115773.Research output: Contribution to journal › Article › peer-review