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Drawing on one of the world’s largest biorepositories of blood and cerebrospinal fluid from well‑characterized older adults, the Knight Alzheimer Disease Research Center Fluid Biomarker Core supports global Alzheimer research by collecting, managing and sharing biospecimens and performing advanced fluid biomarker assays to advance understanding of Alzheimer disease and related disorders.

Research profile

Drawing on one of the world’s largest biorepositories of blood and cerebrospinal fluid from well‑characterized older adults, the Knight Alzheimer Disease Research Center Fluid Biomarker Core supports global Alzheimer research by collecting, managing and sharing biospecimens and performing advanced fluid biomarker assays to advance understanding of Alzheimer disease and related disorders.

Investigating cerebrovascular diseases and vascular cognitive impairment using brain imaging, blood sampling and cognitive testing, with a focus on rare inherited conditions like sickle cell anemia, RVCL-S and CADASIL.

Research profile

Investigates how reactive astrocytes and neuroinflammation contribute to neurodegenerative diseases like Alzheimer’s. Using biochemistry, molecular biology, cellular inflammation models and mouse studies, the lab aims to uncover mechanisms of astrocyte-driven neurotoxicity and develop therapies that target these pathways to reduce brain inflammation.

Research profile

Investigating the molecular mechanisms behind peripheral neuropathy to develop effective treatments. Using both clinical and experimental models, the lab focuses on axon degeneration, neuron-glia interactions and chemotherapy-induced neuropathy to improve patient outcomes and quality of life.

Research profile

Guided by a commitment to compassionate expertise, the WashU Medicine Adult Neurology team provides comprehensive care for patients facing a wide range of neurologic disorders. Our internationally recognized specialists combine clinical excellence with groundbreaking research to treat conditions such as Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis and seizures. Patients also benefit from access to innovative clinical trials, offering hope and new possibilities in the understanding and treatment of complex neurological conditions.

Investigating the genetic, cellular and molecular causes of nervous system dysfunction. Using neurofibromatosis type 1 as a model, the lab applies advanced tools like engineered mice, stem cells and multi-omic analysis to uncover disease mechanisms and develop personalized treatments.

Research profile

Dedicated to enhancing the lives of individuals with headache disorders, our center offers a comprehensive approach that integrates patient care, education and cutting-edge research. Through state-of-the-art evaluations and personalized treatment plans — including medications, trigger management, physical therapy and biobehavioral strategies — our team provides holistic support. In addition to clinical services, the center advances the field through innovative research and educational programs for both patients and healthcare professionals.

Leading research into the mechanisms of neurodegeneration, with a focus on Alzheimer’s disease. Through studies on proteins like apoE and tau, and factors such as sleep, immune response and neuronal activity, the lab aims to uncover pathways that drive disease progression and identify targets for therapy.

Research profile