Hyrc Lab

Krzysztof Hyrc, PhD, is originally from Krakow, Poland. He received his MSc (summa cum laude) in biology in 1981 and his PhD in cellular biophysics in 1987 from Jagielloniasn University in Krakow, Poland. Hyrc completed his first postdoctoral training at the Department of Physiology and Biophysics, University of Miami, Florida. In 1990, he returned from Miami to his native Krakow and was appointed an instructor at the Institute of Molecular Biology, Jagiellonian University. In 1995, Hyrc came to Washington University School of Medicine to work as a research associate before being appointed a research Instructor in 2001.

Hyrc is primarily interested in ionic mechanisms of excitotoxic neuronal cell death. He specializes in intracellular ion concentration measurements using optical techniques, particularly low affinity calcium indicators.

Resources

• Alafi Neuroimaging Laboratory
• Hope Center for Neurological Disorders
• Live Cell Imaging Facility (LCIF)
• Research Gate

Principal investigator

Krzysztof Hyrc, PhD

Associate Professor, Neurology

  Hyrc lab

Recent publications

• Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer’s Disease
  June 1, 2023
  Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer’s DiseaseZagorski, K., King, O., Hovakimyan, A., Petrushina, I., Antonyan, T., Chailyan, G., Ghazaryan, M., Hyrc, K. L., Chadarevian, J. P., Davtyan, H., Blurton-Jones, M., Cribbs, D. H., Agadjanyan, M. G. & Ghochikyan, A., Jun 2023, In: International journal of molecular sciences. 24, 12, 9797.Research output: Contribution to journal › Article › peer-review
• Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury
  March 1, 2023
  Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal InjuryGuo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D., Ozcan, M., Chirinos, J. A., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K., Ma, X., Asnani, A., Shewale, S. V., Scherrer-Crosbie, M., Cowart, L. A., Parks, J. S. & Zhao, L. & 14 others, Gordon, D., Ramirez-Valle, F., Margulies, K. B., Cappola, T. P., Desai, A. A., Pedersen, L. N., Bergom, C., Stitziel, N., Rettig, M., Dipersio, J., Hajny, S., Christoffersen, C., Diwan, A. & Javaheri, A., Mar 2023, In: JACC: Basic to Translational Science. 8, 3, p. […]
• TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis
  March 1, 2022
  TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte HomeostasisMa, X., Rawnsley, D. R., Kovacs, A., Islam, M., Murphy, J. T., Zhao, C., Kumari, M., Foroughi, L., Liu, H., Qi, K., Diwan, A., Hyrc, K., Evans, S., Satoh, T., French, B. A., Margulies, K. B., Javaheri, A., Razani, B., Mann, D. & Mani, K. & 1 others, Diwan, A., Mar 2022, In: JACC: Basic to Translational Science. 7, 3, p. 223-243 21 p.Research output: Contribution to journal › Article › peer-review
• TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy
  November 1, 2019
  TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagyJavaheri, A., Bajpai, G., Picataggi, A., Mani, S., Foroughi, L., Evie, H., Kovacs, A., Weinheimer, C. J., Hyrc, K., Xiao, Q., Ballabio, A., Lee, J. M., Matkovich, S. J., Razani, B., Schilling, J. D., Lavine, K. J. & Diwan, A., Nov 1 2019, In: JCI Insight. 4, 21, e127312.Research output: Contribution to journal › Article › peer-review
• Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets
  June 1, 2019
  Beta-cell excitability and excitability-driven diabetes in adult Zebrafish isletsEmfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D. W., Hyrc, K., Remedi, M. S. & Nichols, C. G., Jun 2019, In: Physiological Reports. 7, 11, e14101.Research output: Contribution to journal › Article › peer-review

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