Hyrc Lab

Krzysztof Hyrc is a cellular biophysicist whose research centers on the ionic mechanisms of excitotoxic neuronal cell death. He specializes in measuring intracellular ion concentrations using advanced optical techniques and is widely recognized for his expertise in low-affinity calcium indicators — critical tools for studying calcium dynamics in neurons.

Originally from Krakow, Poland, Hyrc earned his MSc in biology (summa cum laude) in 1981 and his PhD in cellular biophysics in 1987 from Jagiellonian University. He completed postdoctoral training at the University of Miami’s Department of Physiology and Biophysics, then returned to Jagiellonian University as an instructor at the Institute of Molecular Biology. He joined WashU Medicine in 1995 and was appointed research instructor in 2001.

Resources

• Alafi Neuroimaging Laboratory
• Hope Center for Neurological Disorders
• Live Cell Imaging Facility (LCIF)
• Research Gate

Principal investigator

Recent publications

• Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection
  February 12, 2025
  Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infectionFachi, J. L., de Oliveira, S., Trsan, T., Penati, S., Gilfillan, S., Cao, S., Ribeiro Castro, P., Fernandes, M. F., Hyrc, K. L., Liu, X., Rodrigues, P. F., Bhattarai, B., Layden, B. T., Vinolo, M. A. R. & Colonna, M., Feb 12 2025, In: Cell Host and Microbe. 33, 2, p. 235-251.e7Research output: Contribution to journal › Article › peer-review
• Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer’s Disease
  June 1, 2023
  Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer’s DiseaseZagorski, K., King, O., Hovakimyan, A., Petrushina, I., Antonyan, T., Chailyan, G., Ghazaryan, M., Hyrc, K. L., Chadarevian, J. P., Davtyan, H., Blurton-Jones, M., Cribbs, D. H., Agadjanyan, M. G. & Ghochikyan, A., Jun 2023, In: International journal of molecular sciences. 24, 12, 9797.Research output: Contribution to journal › Article › peer-review
• Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury
  March 1, 2023
  Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal InjuryGuo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D., Ozcan, M., Chirinos, J. A., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K., Ma, X., Asnani, A., Shewale, S. V., Scherrer-Crosbie, M., Cowart, L. A., Parks, J. S. & Zhao, L. & 14 others, Gordon, D., Ramirez-Valle, F., Margulies, K. B., Cappola, T. P., Desai, A. A., Pedersen, L. N., Bergom, C., Stitziel, N., Rettig, M., Dipersio, J., Hajny, S., Christoffersen, C., Diwan, A. & Javaheri, A., Mar 2023, In: JACC: Basic to Translational Science. 8, 3, p. […]
• TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis
  March 1, 2022
  TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte HomeostasisMa, X., Rawnsley, D. R., Kovacs, A., Islam, M., Murphy, J. T., Zhao, C., Kumari, M., Foroughi, L., Liu, H., Qi, K., Diwan, A., Hyrc, K., Evans, S., Satoh, T., French, B. A., Margulies, K. B., Javaheri, A., Razani, B., Mann, D. & Mani, K. & 1 others, Diwan, A., Mar 2022, In: JACC: Basic to Translational Science. 7, 3, p. 223-243 21 p.Research output: Contribution to journal › Article › peer-review
• TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy
  November 1, 2019
  TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagyJavaheri, A., Bajpai, G., Picataggi, A., Mani, S., Foroughi, L., Evie, H., Kovacs, A., Weinheimer, C. J., Hyrc, K., Xiao, Q., Ballabio, A., Lee, J. M., Matkovich, S. J., Razani, B., Schilling, J. D., Lavine, K. J. & Diwan, A., Nov 1 2019, In: JCI Insight. 4, 21, e127312.Research output: Contribution to journal › Article › peer-review

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