Diringer Lab
Michael N. Diringer, MD
All neonatal intensive care unit (NNICU) physicians have specialized research interests directed at improving the care we provide our patients. A unique aspect of this facility is that it is the only Neuro-ICU in the country with a positron emission tomography (PET) scanner located on site. The PET scanner is a tool that can measure brain blood flow and metabolism which are key factors in understanding the impact of our treatments. The PET room is equipped as any other ICU room and contains all the necessary equipment needed to care for a critically ill patient. The facility is funded by grants from the National Institutes of Health.
The NNICU also supports a wide range of other clinical investigations which complement our PET studies.
Current areas of active research include
- Time course of cerebral edema formation around intracerebral hemorrhage
- Glucose metabolism following intracerebral hemorrhage
- Effect of mannitol on sodium homeostasis and osmolality
- Impact of mannitol and hypertonic saline on CBF and brain volume
- Systemic inflammatory response in subarachnoid hemorrhage
- APO-e in subarachnoid hemorrhage
- Hemodynamic augmentation in subarachnoid hemorrhage
- Impact of stains on autoregulation in acute SAH
- Use of prothrombin complex in the reversal of coumadin induced coagulopathy
Principal investigator

Michael Diringer, MD
Professor, Neurology
Professor, Neurosurgery
Associate Professor, Anesthesiology
Associate Professor, Occupational Therapy
- Phone: 314-362-2999
Recent publications
- Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science (Neurocritical Care, (2021), 35, S1, (37-54), 10.1007/s12028-021-01281-6)the Curing Coma Campaign and Its Contributing Collaborators, Jun 2022, In: Neurocritical Care. 36, 3, p. 1080 1 p.Research output: Contribution to journal › Comment/debate
- Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical TrialHergenroeder, G. W., Yokobori, S., Choi, H. A., Schmitt, K., Detry, M. A., Schmitt, L. H., McGlothlin, A., Puccio, A. M., Jagid, J., Kuroda, Y., Nakamura, Y., Suehiro, E., Ahmad, F., Viele, K., Wilde, E. A., McCauley, S. R., Kitagawa, R. S., Temkin, N. R., Timmons, S. D., Diringer, M. N., & 5 othersDash, P. K., Bullock, R., Okonkwo, D. O., Berry, D. A. & Kim, D. H., Apr 2022, In: Neurocritical Care. 36, 2, p. 560-572 13 p.Research output: Contribution to journal › Article › peer-review
- A Precision Medicine Framework for Classifying Patients with Disorders of Consciousness: Advanced Classification of Consciousness Endotypes (ACCESS)The contributing collaborators of the Curing Coma Campaign, Jul 2021, In: Neurocritical Care. 35, p. 27-36 10 p.Research output: Contribution to journal › Article › peer-review
- Research Needs for Prognostic Modeling and Trajectory Analysis in Patients with Disorders of Consciousnessthe Curing Coma Campaign and its Contributing Members, Jul 2021, In: Neurocritical Care. 35, p. 55-67 13 p.Research output: Contribution to journal › Article › peer-review
- Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousnessthe Curing Coma Campaign, Jul 2021, In: Neurocritical Care. 35, p. 4-23 20 p.Research output: Contribution to journal › Article › peer-review