Genes linked to Alzheimer’s disease risk in APOE4 carriers identified

An international team of researchers led by Michael E. Belloy, PhD, assistant professor of neurology and of psychiatry at WashU Medicine, identified key genetic targets for potential Alzheimer’s disease therapeutics development. Targeting specific genes in individuals would allow researchers to take a much more precise approach to Alzheimer’s disease prevention and treatment. Their findings were […]

Three new genetic modifiers connected to risk factors in Alzheimer’s disease

Image showing the three chromosomal locations identified in this study on a graph.

Autosomal dominant Alzheimer’s disease (ADAD) is a form of genetically inherited Alzheimer’s that makes up only about 1% of Alzheimer’s disease occurrences. However, because of the extremely high rate and early age at which individuals with the gene mutations develop Alzheimer’s disease, and also because of the high heritability of the mutation, ADAD is widely […]

New comprehensive data platform could transform how Alzheimer’s disease is studied and treated

With an increasingly aging global population and no available preventative treatments, Alzheimer’s disease and related dementias are poised to become an even larger public health challenge. The mechanisms underlying Alzheimer’s disease are difficult to study because the disease has a long developmental period during which changes in the brain can occur years before symptoms appear. […]

WashU Medicine researchers to build AI tools to boost Alzheimer’s research

WashU Medicine has been awarded nearly $800,000 by the National Artificial Intelligence Research Resource (NAIRR) Pilot program, an initiative of the National Science Foundation (NSF), and Microsoft to develop AI tools aimed at improving biomedical research efficiency, with an initial focus on Alzheimer’s disease. The grant will fund the Consortium for Biomedical Research and AI […]

Aravamuthan and Saligrama celebrated for first NIH R01 grants

On April 8, Washington University School of Medicine in St. Louis recognized investigators who received their first R01 research grants from the National Institutes of Health (NIH). Receiving an R01 grant is an important milestone for scientists who are establishing their careers as independent researchers. Bhooma R. Aravamuthan, MD, DPhil, FAAN, FCNS, assistant professor of […]

Study Reports Successful Results in First Anti-Amyloid Treatment of HIV+ Individual

PET scan images demonstrating absence of amyloid in a patient with HIV cognitive impairment contrasting with image confirming aggregated amyloid in reported patient with Alzheimer Disease.

A new case report published by David B. Clifford, MD, and colleagues detailed the anti-amyloid therapy treatment course of a patient who developed Alzheimer’s disease concurrently with a pre-existing HIV diagnosis. The patient, who was diagnosed with HIV in 2005, began showing signs of cognitive decline in 2015 and received a clinical diagnosis of Alzheimer’s […]

Study Shows Need for Long-Term Follow-up and Evaluation of Children Who Experienced Acute Seizures as Newborns

Radar plot of developmental outcome profiles at age 5 to 6 years for children with a history of acute provoked neonatal seizures. Each group is designated with a different color: green for Typical Development, blue for Behavioral Dysregulation and red for Multi-Domain Impairment. The distance from the center of the plot indicates the percentage of individuals in that group with each outcome. The outcomes include epilepsy, cerebral palsy, ADHD, ASD and others.

Acute provoked neonatal seizures (also known as acute symptomatic neonatal seizures) can occur in newborns whose brains are injured by a range of causes from stroke and bleeding in the brain to central nervous system infections. While the seizures themselves are scary enough for the families, the story continues after the neonates are treated for […]

WashU Neurology ranks No. 2 in NIH funding

A graphic with the words: WashU Medicine Neurology ranks No. 2 in NIH funding among all neurology departments in the U.S.

The Department of Neurology at WashU Medicine is proud to announce that it has been ranked No. 2 in NIH funding among all neurology departments across the U.S. This prestigious ranking reflects the exceptional dedication and groundbreaking work of our faculty, staff and trainees. Department leadership would like to extend their heartfelt gratitude to all […]

Lee, Leuthardt awarded Falk Catalyst grant to fund acute stroke clinical trial

Headshots of Jin-Moo Lee and Eric Leuthardt

Jin-Moo Lee, MD, PhD, head of the WashU Medicine Department of Neurology, and Eric Leuthardt, MD, MBA, vice chair of innovation in the Department of Neurosurgery, have been selected as recipients of the prestigious Falk Catalyst Award. Each year, select institutions are invited to submit up to two applications to the Dr. Ralph and Marian […]

Orr lab named first-ever Bruker Spatial Biology Center of Excellence

Orr lab ribbon cutting as the first-ever Bruker Spatial Biology Center of Excellence

This designation recognizes Miranda Orr, PhD, associate professor of Neurology, and her team as global leaders in spatial biology, providing access to pre-commercial technologies and close partnership with Bruker Spatial Biology to advance the next generation of discovery.