Novel Gene Therapy Clinical Trial Targets Rett Syndrome

Gloved hands hold syringe to glass vial

Washington University School of Medicine in St. Louis is one of only ten sites in the world participating in a pioneering clinical trial evaluating TSHA-102, an investigational gene therapy for the treatment of Rett syndrome, a severe neurodevelopmental disorder primarily affecting girls. The REVEAL Phase 1/2 clinical trial represents a significant advancement in the quest […]

Staff Spotlight Jacki Mallmann

Jacki Mallmann

Jacki Mallmann began her career at Washington University School of Medicine in St. Louis in 1998 as a part-time administrative assistant in the Department of Psychiatry. She spent fourteen years working at the Midwest Alcoholism Research Center, where she gained invaluable administrative research experience by working on multiple NIH-funded studies, IRB submissions, data entry, general […]

Study highlights barriers to genetic testing for Black children (Links to an external site)

A recent study by WashU Medicine researchers found Black children were about half as likely as white children to obtain genetic testing ordered by their neurologists. The results are already changing practice at WashU Medicine’s pediatric neurology clinic, where a genetic counselor has been embedded to help address some of the access challenges uncovered by the study.

Studies have shown that Black children with serious illnesses are less likely than white children to obtain crucial genetic testing necessary to guide treatment decisions, but the reasons for this disparity have not been fully understood. A new study from Washington University School of Medicine in St. Louis focused on children with neurological conditions finds […]

Next-gen Alzheimer’s drugs extend independent living by months (Links to an external site)

An Alzheimer’s patient with very mild symptoms who undergoes treatment with one of the new, next-generation therapies could expect to gain eight or 10 months living independently, according to a study by researchers at WashU Medicine. The new analysis interprets the benefits of the drugs in a way that is meaningful to patients and families, to help them make informed decisions about treatment.

In the past two years, the Food and Drug Administration has approved two novel Alzheimer’s therapies, based on data from clinical trials showing that both drugs slowed the progression of the disease. But while the approvals of lecanemab and donanemab, both antibody therapies that clear plaque-causing amyloid proteins from the brain, were greeted with enthusiasm […]

Generous donation from Jansky/Bander Family to fund Movement Disorders fellowships, support brain bank

Generous donation funds Movement Disorders fellowships, supports brain bank

The Jansky/Bander Family Fund, a generous commitment of $1,100,000 over five years, has been established to advance critical initiatives within the Section of Movement Disorders at Washington University School of Medicine in St. Louis Department of Neurology. This significant financial contribution is earmarked for two primary functions under the direction of Joel Perlmutter, MD: funding […]

Patient defies genetic fate to avoid Alzheimer’s (Links to an external site)

Doug Whitney, who lives near Seattle, Wash., inherited a mutation that has caused many family members to develop Alzheimer's disease at about age 50, yet he shows no sign of the illness at age 75. His case is the subject of a new study by WashU Medicine researchers that aims to identify potential routes to preventing or treating Alzheimer's based on Whitney's exceptional resilience to the disease.

Remarkably, Doug Whitney, 75, has escaped genetic destiny. Like many members of his family, Whitney inherited a rare genetic mutation that all but guarantees he would develop early-onset Alzheimer’s disease. But Whitney, whose relatives first showed symptoms of cognitive decline in their early 50s, remains mentally sharp with no signs of the devastating disease, and […]

Three Neurology nurses 2025 Excellence in Nursing Awards finalists!

ST. LOUIS MAGAZINE

Three of our incredibly hard-working nurses at WashU Medicine Department of Neurology were selected as 2025 Excellence in Nursing Awards finalists — Ashley Rabe, Wendy Sanders and Audra Stewart! The annual St. Louis Magazine Excellence in Nursing Awards, presented by BJC HealthCare and Goldfarb School of Nursing at Barnes-Jewish College, recognizes nurses across the St. Louis region […]

Jiang-Xie selected for 2024 WashU Medicine Bold Pioneer Award

WashU Medicine Bold Pioneer Award 2024 Winner: Li-Feng Jiang-Xie, PhD

Li-Feng Jiang-Xie, PhD, a postdoctoral research associate in WashU Medicine Department of Pathology and Immunology, has been selected as the winner of the 2024 WashU Medicine Bold Pioneer Award. A ceremony to celebrate the winner will be held Friday, May 2 at 4 p.m. in the Jeffrey T. Fort Neuroscience Research Building Auditorium on the […]

International Alzheimer’s prevention trial in young adults begins (Links to an external site)

Primary Prevention trial participant Hannah Richardson, 24, undergoes a clinical exam given by WashU Medicine neurologist Nupur Ghoshal, MD, PhD. The international trial, led by WashU Medicine, aims to determine whether stopping the early molecular changes that lead to symptomatic Alzheimer’s disease can prevent the disease from ever taking hold.

The first participants in an international clinical trial aimed at preventing Alzheimer’s disease in young adults at high risk of the disease have been enrolled. The trial, led by Washington University School of Medicine in St. Louis, aims to determine whether stopping the early molecular changes that lead to symptomatic Alzheimer’s disease can prevent the […]

Foster to be inducted into AOTA’s Roster of Fellows (Links to an external site)

Congratulations to Erin Foster, PhD, OTD, OTR/L who will receive the American Occupational Therapy Association’s (AOTA’s) Roster of Fellows Award at AOTA’s Inspire 2025 Annual Conference & Expo in Philadelphia, Pa. The Roster of Fellows recognizes occupational therapists who through their knowledge, expertise, leadership, advocacy, and/or guidance have made a significant contribution over time to […]