Brains of people with sickle cell disease appear older (Links to an external site)

A new study led by WashU Medicine researchers has found older-looking brains in adults with sickle cell disease, helping to explain the cognitive challenges experienced by such individuals. A brain image from a healthy individual (left) shows a larger brain with more white matter compared with a brain image from a patient with sickle cell disease (right). Healthy individuals experiencing economic deprivation also had more-aged appearing brains.

Individuals with sickle cell disease – a chronic illness where misshapen, sticky blood cells clump together, reducing oxygen delivery to organs – are at a higher risk for stroke and resulting cognitive disability. But even in the absence of stroke, many such patients struggle with remembering, focusing, learning and problem solving, among other cognitive problems, […]

New Qalsody Results Bring Hope for Recovery of Lost Function and More Time (Links to an external site)

For decades, the general consensus among neurologists and neuroscientists has been that ALS treatments would only be able to slow down or stop further progression of the disease. Function that had already been lost would probably not be recovered. But now, evidence is emerging that not only is functional improvement possible, it’s happening for some people […]

Could inhaling xenon gas help treat Alzheimer’s? A new mouse study suggests it might (Links to an external site)

A medical device used for xenon therapy. Adobe

The gas xenon, like the other noble, or inert, gases, is known for doing very little. The class of elements, because of its molecular structure, don’t typically interact with many chemicals.  But a new mouse study shows one possible use case for xenon — as a treatment for Alzheimer’s disease. The paper, published Wednesday in Science Translational […]

2025-2026 Academic Year Neurology Residency Program Chief Residents

The Department of Neurology is pleased to announce our Neurology Residency Program chief residents for the 2025-2026 academic year. This group of remarkable individuals will be working with their resident colleagues, staff, faculty and leadership to continue strengthening our program as a leader in neurology residency training. Thank you to our current chief residents, Drs. […]

Major Depression in Older Adults Tied to Risky Driving Behaviors (Links to an external site)

Older adults with major depressive disorder (MDD) exhibit riskier driving behaviors than their nondepressed peers, including hard braking, cornering, and unpredictable driving patterns, new research showed. Data for the study came from commercial vehicle data trackers installed in participants’ vehicles. After about a year of follow-up, investigators found that MDD was associated with an increase […]

Congratulations to Neurology’s November 2024 SAFE accolade recipients

SAFE accolades - Neurology

Congratulations to the members of the Department of Neurology who received accolades through the Supporting a Fair Environment (SAFE) program! SAFE aims to improve the learning environment by promoting positive behaviors and managing concerns about learner mistreatment and unprofessional behaviors. SAFE accolades include treating others with dignity and respect, creating an environment that values diversity, […]

Vagus nerve stimulation relieves severe depression (Links to an external site)

The vagus nerves (orange) run from the brain through the neck to the internal organs. People with severe, treatment-resistant depression who received vagus nerve stimulation therapy showed improvement in depressive symptoms, quality of life, and ability to complete the tasks of daily life, according to a national clinical trial led by researchers at WashU Medicine.

People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial led by Washington University School of Medicine in St. Louis.  The findings are published Dec. 18 in a […]