Neurodegeneration
Perlmutter Lab
Joel S. Perlmutter, MD
Investigating movement disorders like Parkinson’s disease and dystonia. Through neuroimaging, deep brain stimulation studies and translational research, the lab explores brain physiology, develops biomarkers and tests therapies to improve diagnosis, treatment and understanding of these conditions.
Pottier Lab
Cyril P. Pottier, PhD
Investigating genetic drivers and biomarkers of early-onset dementias, including young-onset Alzheimer’s disease and frontotemporal dementia, using multi-omics approaches to uncover therapeutic targets and modifiers.
Weihl Lab
Conrad Weihl, MD, PhD
Investigating how disruptions in protein quality control contribute to muscle and neurodegenerative diseases. Using biochemistry, cell culture, animal models and patient tissue, the lab studies conditions like inclusion body myopathy, Paget’s disease, frontotemporal dementia and limb-girdle muscular dystrophy to uncover mechanisms of protein aggregation and cellular degeneration. [weihllab.wustl.edu]
Zhao Lab
Guoyan Zhao, PhD
Department of Genetics
Exploring transcriptional regulation in the nervous system using computational and experimental methods to understand mechanisms behind chronic pain and neurodegenerative diseases such as Alzheimer, Parkinson and Lewy body disorders.