Clifford Lab
David Clifford, MD
David Clifford, MD, is the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology at Washington University in St. Louis. A primary career goal has been to improve therapeutics for neurological disorders with a particular focus on neurological complications of HIV. Since 1993, he has led the Neurologic AIDS Research Consortium, an NIH funded national research group designed to develop improved therapy for neuroAIDS complications. He is the principal investigator of the AIDS Clinical Trials Unit at Washington University which is the premier international NIH funded AIDS therapeutic network. He is also an active investigator in the CHARTER study, a multicenter epidemiologic group studying neuroAIDS. He currently is co-PI for the Vanderbilt AIDS Clinical Trials Unit, which includes the Washington University Clinical Research Site. He has a specific focus on understanding the interaction of aging in the setting of chronic HIV infection.
Clifford is also the principal investigator for the Washington University NeuroNEXT trial unit, one of 25 centers designed to accelerate Phase 2 clinical trials for neurological disorders. He has led international research relevant to HIV and the nervous system in Ethiopia, Uganda, The Gambia, Guinea Bissau, Senegal and Thailand. He is also currently participating as an investigator at the Knight Alzheimer Disease Research projects at Washington University and is medical director for the Dominant Inherited Alzheimer Disease Treatment Trial (DIAN-TU) — the first pre-symptomatic controlled trial for treatment to prevent the onset of dementia in the inherited form of Alzheimer Disease.
Principal investigator
David Clifford, MD
Professor of Neurology
Chief, Adult Neuroinfectious Diseases
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology
- Phone: 314-747-8423
Recent publications
- Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trialDominantly Inherited Alzheimer's Disease–Trials Unit, Apr 2025, In: The Lancet Neurology. 24, 4, p. 316-330 15 p.Research output: Contribution to journal › Article › peer-review
- Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical TrialWagemann, O., Liu, H., Wang, G., Shi, X., Bittner, T., Scelsi, M. A., Farlow, M. R., Clifford, D. B., Supnet-Bell, C., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J. J., Benzinger, T. L. S., Gordon, B. A., Coalier, K. A., Cruchaga, C., Ibanez, L., Perrin, R. J., Xiong, C. & Li, Y. & 30 others, Morris, J. C., Lah, J. J., Berman, S. B., Roberson, E. D., Van Dyck, C. H., Galasko, D., Gauthier, S., Hsiung, G. Y. R., Brooks, W. S., Pariente, J., […]
- Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical TrialsLiu, H., Li, J., Ziegemeier, E., Adams, S., McDade, E., Clifford, D. B., Cao, Y., Wang, G., Li, Y., Mills, S. L., Santacruz, A. M., Belyew, S., Grill, J. D., Snider, B. J., Mummery, C. J., Surti, G., Hannequin, D., Wallon, D., Berman, S. B. & Jimenez-Velazquez, I. Z. & 19 others, Roberson, E. D., van Dyck, C. H., Honig, L. S., Sanchez-Valle, R., Brooks, W. S., Gauthier, S., Galasko, D., Masters, C. L., Brosch, J., Hsiung, G. Y. R., Jayadev, S., Formaglio, M., Masellis, M., […]
- Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's diseaseWang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre-Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., Fox, N. C. & Suzuki, K. & 5 others, Levin, J., Jucker, M., Delmar, P., Bittner, T. & Bateman, R. J., Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2698-2706 9 […]
- Mycobacterium haemophilum Related Myelitis in Geographically Linked CasesSamudralwar, R. D., Bailey, T. C., Vellimana, A. K., Wright, N. M. & Clifford, D. B., Mar 2024, In: Annals of neurology. 95, 3, p. 614-616 3 p.Research output: Contribution to journal › Article › peer-review