Clifford Lab

David Clifford, MD

David Clifford, MD, is the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology at Washington University in St. Louis. A primary career goal has been to improve therapeutics for neurological disorders with a particular focus on neurological complications of HIV. Since 1993, he has led the Neurologic AIDS Research Consortium, an NIH funded national research group designed to develop improved therapy for neuroAIDS complications. He is the principal investigator of the AIDS Clinical Trials Unit at Washington University which is the premier international NIH funded AIDS therapeutic network. He is also an active investigator in the CHARTER study, a multicenter epidemiologic group studying neuroAIDS. He currently is co-PI for the Vanderbilt AIDS Clinical Trials Unit, which includes the Washington University Clinical Research Site. He has a specific focus on understanding the interaction of aging in the setting of chronic HIV infection.

Clifford is also the principal investigator for the Washington University NeuroNEXT trial unit, one of 25 centers designed to accelerate Phase 2 clinical trials for neurological disorders. He has led international research relevant to HIV and the nervous system in Ethiopia, Uganda, The Gambia, Guinea Bissau, Senegal and Thailand. He is also currently participating as an investigator at the Knight Alzheimer Disease Research projects at Washington University and is medical director for the Dominant Inherited Alzheimer Disease Treatment Trial (DIAN-TU) — the first pre-symptomatic controlled trial for treatment to prevent the onset of dementia in the inherited form of Alzheimer Disease.

Principal investigator

David Clifford, MD

Professor, Neurology and Medicine
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology
Section Head, Neuroinfectious Diseases

Recent publications

  • The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cellsPaley, M. A., Baker, B. J., Dunham, S. R., Linskey, N., Cantoni, C., Lee, K., Hassman, L. M., Laurent, J., Roberson, E. D. O., Clifford, D. B. & Yokoyama, W. M., Jun 15 2022, In: Journal of Neuroimmunology. 367, 577860.Research output: Contribution to journal › Article › peer-review
  • Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Modelfor the CHARTER Study Group, Jun 2022, In: AIDS and Behavior. 26, 6, p. 1966-1979 14 p.Research output: Contribution to journal › Article › peer-review
  • Neuropathic pain correlates with worsening cognition in people with human immunodeficiency virusEllis, R. J., Sacktor, N., Clifford, D. B., Marra, C. M., Collier, A. C., Gelman, B., Robinson-Papp, J., Letendre, S. L. & Heaton, R. K., Jun 1 2022, In: Brain. 145, 6, p. 2206-2213 8 p.Research output: Contribution to journal › Article › peer-review
  • Ethnic/Racial Disparities in Longitudinal Neurocognitive Decline in People With HIVWei-Ming Watson, C., Kamalyan, L., Tang, B., Hussain, M. A., Cherner, M., Rivera Mindt, M., Byrd, D. A., Franklin, D. R., Collier, A. C., Clifford, D. B., Gelman, B., Morgello, S., McCutchan, J. A., Ellis, R. J., Grant, I., Heaton, R. K. & Marquine, M. J., May 1 2022, In: Journal of Acquired Immune Deficiency Syndromes. 90, 1, p. 97-105 9 p.Research output: Contribution to journal › Article › peer-review
  • Peripheral inflammation and depressed mood independently predict neurocognitive worsening over 12 yearsTang, B., Collier, A. C., Morgello, S., Cookson, D., Sacktor, N., Ellis, R. J., Marra, C. M., Clifford, D. B., Gelman, B. B., Robinson-Papp, J., McCutchan, J. A., Letendre, S., Heaton, R. K. & Grant, I., May 2022, In: Brain, Behavior, and Immunity – Health. 21, 100437.Research output: Contribution to journal › Article › peer-review