Is There a Possible Connection Between HIV Infection and a Lower Risk of Multiple Sclerosis? (Links to an external site)

Image of a virus

An analysis of two large, population-based databases suggests that people with human immunodeficiency virus (HIV) are at lower risk for developing multiple sclerosis (MS), a finding hinted at in previous research. In particular, people who are HIV-positive with a history of taking antiretroviral therapy (ART) were less likely to develop MS than people in the […]

Clues to preventing Alzheimer’s come from patient who, despite genetics, evaded disease (Links to an external site)

A woman who never developed Alzheimer's despite a strong genetic predisposition may hold the key to stopping the disease in its tracks. Studying the woman's unique complement of genetic mutations, researchers at Washington University School of Medicine in St. Louis have found clues that could help cut the link between the early, asymptomatic stage and the late stage, when cognitive decline sets in.

Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop dementia in their 40s, she stayed cognitively healthy into her […]

Long-standing hormone treatment for donated hearts found to be ineffective (Links to an external site)

Washington University physician Raj Dhar, MD, (front) and Gary Marklin, MD, the chief medical officer at Mid-America Transplant in St. Louis, care for a deceased organ donor. Dhar and Marklin led a study that showed that the long-standing practice of treating deceased organ donors with thyroid hormone does not help preserve heart function, may cause harm and should be discontinued.

Doctors managing deceased organ donors routinely treat the donors’ bodies with thyroid hormones in a bid to preserve heart function and increase the quantity and quality of hearts and other organs available for transplantation. However, according to a recent clinical trial led by researchers at Washington University School of Medicine in St. Louis and Mid-America […]

Tuberous Sclerosis Center at Washington University School of Medicine in St. Louis expands with addition of Adult TSC Director Nascimento

Fábio A. Nascimento, MD, and Patty Schaefer examine a patient

The Washington University Tuberous Sclerosis Center is recognized by the Tuberous Sclerosis Complex Alliance as one of only 13 TSC Centers of Excellence across the globe and the only in Missouri. Its multispecialty team is equipped to provide the highest level of comprehensive, medical care for children and adults with tuberous sclerosis complex while conducting cutting-edge […]

How do toxic proteins accumulate in Alzheimer’s and other diseases? (Links to an external site)

Stress granules (red) fill stem cell-derived neurons (nuclei shown in blue) from a person with a mutation in the tau gene. Researchers at Washington University School of Medicine in St. Louis have figured out the connection between tau mutations and stress granules, a discovery which could potentially lead to new approaches to treating a group of neurodegenerative diseases known as tauopathies.

Under normal circumstances, tau protein is part of the brain’s infrastructure, important for stabilizing neurons into their proper shapes. But sometimes tau gets knotted up into tangles and turns toxic, injuring brain tissue and causing tauopathies, a group of brain diseases characterized by problems with learning, memory and movement. Alzheimer’s disease is the most common […]