Study Reports Successful Results in First Anti-Amyloid Treatment of HIV+ Individual

PET scan images demonstrating absence of amyloid in a patient with HIV cognitive impairment contrasting with image confirming aggregated amyloid in reported patient with Alzheimer Disease.

A new case report published by David B. Clifford, MD, and colleagues detailed the anti-amyloid therapy treatment course of a patient who developed Alzheimer’s disease concurrently with a pre-existing HIV diagnosis. The patient, who was diagnosed with HIV in 2005, began showing signs of cognitive decline in 2015 and received a clinical diagnosis of Alzheimer’s […]

Blood test “clocks” predict when Alzheimer’s symptoms will start (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have developed a method to predict when someone is likely to develop symptoms of Alzheimer’s disease using a single blood test. In a new study published Feb. 19 in Nature Medicine, the researchers demonstrated that their models predicted the onset of Alzheimer’s symptoms within a […]

Study Shows Need for Long-Term Follow-up and Evaluation of Children Who Experienced Acute Seizures as Newborns

Radar plot of developmental outcome profiles at age 5 to 6 years for children with a history of acute provoked neonatal seizures. Each group is designated with a different color: green for Typical Development, blue for Behavioral Dysregulation and red for Multi-Domain Impairment. The distance from the center of the plot indicates the percentage of individuals in that group with each outcome. The outcomes include epilepsy, cerebral palsy, ADHD, ASD and others.

Acute provoked neonatal seizures (also known as acute symptomatic neonatal seizures) can occur in newborns whose brains are injured by a range of causes from stroke and bleeding in the brain to central nervous system infections. While the seizures themselves are scary enough for the families, the story continues after the neonates are treated for […]

WashU Neurology ranks No. 2 in NIH funding

A graphic with the words: WashU Medicine Neurology ranks No. 2 in NIH funding among all neurology departments in the U.S.

The Department of Neurology at WashU Medicine is proud to announce that it has been ranked No. 2 in NIH funding among all neurology departments across the U.S. This prestigious ranking reflects the exceptional dedication and groundbreaking work of our faculty, staff and trainees. Department leadership would like to extend their heartfelt gratitude to all […]

Brain network responsible for Parkinson’s disease identified (Links to an external site)

The brain network that links thinking with movement, called SCAN, was first described by WashU Medicine researchers in 2023 and has been identified in a new study as the neurological basis of Parkinson’s disease. An experimental therapy that targeted this network more than doubled symptom improvement in a small group of patients with Parkinson’s, which is characterized by hyperconnectivity (left side of illustration) between SCAN and the brain’s subcortex.

Parkinson’s disease, a progressive neurological disorder affecting more than 1 million people in the U.S. and more than 10 million globally, is characterized by debilitating symptoms such as tremors, movement difficulties, sleep disturbances and cognitive impairments. While current treatments, including long-term medication and invasive deep brain stimulation (DBS), can alleviate symptoms, they cannot halt progression […]

Breathing disruptions during sleep widespread in newborns with severe spina bifida (Links to an external site)

NICU baby laying on their stomach

Children with spina bifida, a malformation of the spinal cord that can lead to mobility impairments and hydrocephalus — a buildup of fluid in the brain — face significant risk of cognitive difficulties throughout their lives. A new multi-center study led by researchers at Washington University School of Medicine in St. Louis and Michigan Medicine […]

WashU startups attract record-setting $1.7 billion in private-sector investment over past year (Links to an external site)

Inside Wugen laboratory, people in white lab coats and purple gloves work at various lab stations.

Startup companies built on Washington University in St. Louis discoveries attracted a record $1.7 billion in private-sector investment over the past year, accelerating the commercialization of WashU innovations into life-changing diagnostics, therapeutics and medical devices. Among those innovations are a blood test to diagnose Alzheimer’s disease; immunotherapies to treat aggressive blood cancers; and an AI-based […]