Linde Jacobs paced back and forth across her bedroom, eyeing the open laptop on the dresser and willing the doctor to appear. Her husband was dropping off their older daughter at school. Their younger daughter was downstairs, occupied by a screen. Linde wanted to be alone when she learned whether she carried the family curse.
Category: Research
Vagus nerve stimulation relieves severe depression (Links to an external site)
People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial led by Washington University School of Medicine in St. Louis. The findings are published Dec. 18 in a […]
NIH grant funds study of cerebral small vessel disease (Links to an external site)
Researchers at Washington University School of Medicine in St. Louis have been awarded $7.5 million from the National Institutes of Health (NIH) to investigate a form of dementia caused by cerebral small vessel disease, the second-leading cause of dementia after Alzheimer’s disease.
Grant will fund development of vaccines to prevent dementia (Links to an external site)
Alzheimer’s disease and frontotemporal dementia are devastating disorders that emerge following the buildup of misfolded proteins in the brain. The newest generation of Alzheimer’s therapeutics targets accumulations of the protein amyloid beta with engineered antibodies, but the results have been underwhelming, with some adverse effects, not to mention using engineered antibodies can be prohibitively expensive.
WashU Medicine reaches all-time high in NIH funding (Links to an external site)
In a testament to the quality and national competitiveness of biomedical research at Washington University School of Medicine in St. Louis, the school secured $683 million in research funding from the National Institutes of Health (NIH) in federal fiscal year 2024 – a record high for WashU Medicine and an affirmation of its leadership in […]
The potential of psychedelic-assisted therapy (Links to an external site)
More than half a century after the U.S. government deemed psychedelic drugs to be of “no medical use,” scientists have begun re-evaluating that dismissive assessment with the tools of modern science. Dozens of clinical trials of psychedelic-assisted therapies for depression, anxiety, post-traumatic stress disorder (PTSD) and other conditions are underway or planned. So far, the results […]
Why a St. Louis startup is giving away its pandemic-thwarting idea (Links to an external site)
Recall how long it took, in the depths of the COVID-19 pandemic, to screen yourself with the gold-standard method, the PCR test: You’d swab your nostrils, hand the swab to the person at the pharmacy or clinic, then wait while they sent it off to a lab for processing. Yes, the result was highly reliable, […]
Researchers define new subtypes of common brain disorder (Links to an external site)
Roughly 4% of the population is affected by a congenital brain malformation that has eluded researchers’ efforts to find causes and treatments. For the condition, Chiari type-1 malformation, the diagnosis is straightforward: the lower part of the brain, known as the cerebellum, protrudes at least five millimeters through the gap in the skull that connects […]
New drug targets for Alzheimer’s identified from cerebrospinal fluid (Links to an external site)
A multitude of genes have been linked to the development of Alzheimer’s disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient. Using cerebrospinal fluid (CSF) collected from living patients, […]
Healthy brains suppress inappropriate immune responses (Links to an external site)
The brain constantly engages in dialogue with the body’s immune system. Such communication appears aimed at ensuring a delicate balance between defending against injury and infection and guarding healthy tissue.