Alzheimer’s blood test detects disease decades before symptoms, aiding drug search

Getty Images A woman with Alzheimer's performs a memory exercise in a nursing home.

Alzheimer’s remains a deadly and incurable disease that affects 5.5 million Americans. It is one of the greatest threats to the solvency of Medicare. New blood tests can identify patients up to 20 years before physical symptoms. This could prove crucial in developing preventative treatments. Published 10:00 AM ET Mon, 5 March 2018 Updated 10:25 […]

Body clock disruptions occur years before memory loss in Alzheimer’s (Links to an external site)

People with Alzheimer’s disease have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Researchers at Washington University School of Medicine in St. Louis have found that such circadian rhythm disruptions also occur much earlier in people whose memories are intact but whose brain scans show early, preclinical evidence of Alzheimer’s.

People with Alzheimer’s disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Now, new research at Washington University School of Medicine in St. Louis indicates that such circadian rhythm disruptions also occur much earlier in people whose memories are intact […]

Alzheimer’s gene poses both risk — and benefits (Links to an external site)

Immune cells are more activated (red) in the brains of mice with the gene TREM2 (left) than in those without the gene (right). A new study shows that having a working copy of the gene TREM2 can reduce risk of Alzheimer’s disease under certain conditions but worsen disease in others.

Scientists drilling down to the molecular roots of Alzheimer’s disease have encountered a good news/bad news scenario. A major player is a gene called TREM2, mutations of which can substantially raise a person’s risk of the disease. The bad news is that in the early stages of the disease, high-risk TREM2 variants can hobble the immune system’s ability to […]