COBRAS Seminar Series

“Clock Hijackers: Circadian signaling in glioblastoma synchronizes tumor daily rhythms and regulates tumor progression”

Glioblastoma (GBM) is a deadly brain tumor that, unlike other cancers, sustains intrinsic circadian rhythms in clock gene expression that synchronize to the host. We now find that daily glucocorticoid receptor signaling acts as an intrinsic driver of GBM progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.

Dr. Maria Felicita Gonzalez-Aponte
Postdoctoral Research Associate (Herzog Lab)
Arts & Sciences, Department of Biology
Washington University in St. Louis

Join us in person in Holden Auditorium
Zoom: https://wustl-hipaa.zoom.us/j/95243853618

Friday, February 21, 2025
Noon – 1:00 pm
Holden Auditorium, FLTC
1-hour CME available for this lecture