Wu Lab

The main goal of our research is to define the regulation of adaptive immune responses during inflammation within the central nervous system (CNS). The Wu lab has several areas of ongoing investigation into the pathogenesis of multiple sclerosis (MS) and related diseases. We are exploring characteristics of monocytes, microglia and B cells from patients to better understand cell-intrinsic abnormalities underpinning neuroimmunologic dysregulation in human diseases.

Additionally, we are modeling cellular and molecular immune contributions to neuro-inflammation by utilizing various experimental autoimmune encephalomyelitis (EAE) systems. Finally, we are actively engaged in several clinical trials to identify new highly efficacious disease-modifying therapies and mechanisms of action for currently approved MS therapies.

Principal investigator

Our team

Recent publications

• A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
  January 2, 2025
  A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populationsCantoni, C., Smirnov, R. A., Firulyova, M., Andhey, P. S., Bradstreet, T. R., Esaulova, E., Terekhova, M., Schwarzkopf, E. A., Abdalla, N. M., Kleverov, M., Sabatino, J. J., Liu, K., Schwab, N., Meyer Zu Hörste, G., Cross, A. H., Artyomov, M. N., Edelson, B. T. & Wu, G. F., Jan 2 2025, In: Journal of Clinical Investigation. 135, 1, e177793.Research output: Contribution to journal › Article › peer-review
• Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis
  August 20, 2024
  Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosisGhezzi, L., Tosti, V., Shi, L., Cantoni, C., Mikesell, R., Lancia, S., Zhou, Y., Obert, K., Dula, C., Sen, M. K., Ge, A., Tolentino, M., Bollman, B., Don, A. S., Matarese, G., Colamatteo, A., La Rocca, C., Lepore, M. T., Raji, C. A. & Rahmani, F. & 6 others, Wu, G. F., Naismith, R. T., Fontana, L., Cross, A. H., Salter, A. & Piccio, L., Aug 20 2024, In: Journal of Neurology, Neurosurgery and Psychiatry. 96, 2Research output: Contribution to journal › Article › peer-review
• Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restriction
  August 1, 2024
  Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restrictionMartin, K., Cofield, S. S., Cross, A. H., Goss, A. M., Raji, C. A., Rinker, J. R., Wu, G. F., Blair, J., Fuchs, A., Ghezzi, L., Green, K., Pace, F., Pastori, G., Taylor, M. G., Piccio, L. & Wingo, B. C., Aug 2024, In: Contemporary Clinical Trials. 143, 107584.Research output: Contribution to journal › Article › peer-review
• Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseases
  June 15, 2024
  Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseasesTrivedi, R. R., Archambault, A. S., Pavlak, C., Gastaldi, M., Cantoni, C., Ghezzi, L., Cross, A. H., Miller, T. M. & Wu, G. F., Jun 15 2024, In: Journal of the Neurological Sciences. 461, 123041.Research output: Contribution to journal › Article › peer-review
• Sex differences in plasma proteomic markers in late-life depression
  April 1, 2024
  Sex differences in plasma proteomic markers in late-life depressionXue, X., Demirci, D., Lenze, E. J., Reynolds III, C. F., Mulsant, B. H., Wetherell, J. L., Wu, G. F., Blumberger, D. M., Karp, J. F., Butters, M. A., Mendes-Silva, A. P., Vieira, E. L., Tseng, G. & Diniz, B. S., Apr 2024, In: Psychiatry Research. 334, 115773.Research output: Contribution to journal › Article › peer-review