Saligrama Lab
Naresha Saligrama, PhD
The Saligrama Lab is dedicated to understanding adaptive immune responses in both healthy states and neurological disorders. Recent research increasingly shows that inflammation and adaptive immunity play important roles in normal aging and in the development of neurological conditions.
T cell diversity and antigen recognition
T cells are a key component of the adaptive immune system, recognizing a wide range of antigens through their T-cell receptors (TCRs). A major challenge in studying T cell responses is the vast diversity of TCRs and the variety of antigens they can encounter.
Sequence-based approach to T cell analysis
To address this challenge, the lab has developed a sequence-based method for single T cell TCR sequencing and phenotyping. This includes a bioinformatics pipeline that clusters TCR sequences based on shared antigen specificity.
High-throughput antigen discovery
In contrast to traditional approaches that rely on prior knowledge of antigens, the lab has created unbiased high-throughput technologies to identify TCR antigen specificity. These tools allow for a systems-level exploration of T cell responses.
Applications in neurological disorders
Using these advanced technologies, the lab investigates T cell responses across a range of conditions, including:
- Neuropsychiatric conditions
- Neuroinflammatory disorders
- Neurodegenerative diseases
Principal investigator
Our team
Recent publications
- Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsilsSureshchandra, S., Henderson, J., Levendosky, E., Bhattacharyya, S., Kastenschmidt, J. M., Sorn, A. M., Mitul, M. T., Yates, T. B., Cheng, E., Benchorin, A., Batucal, K., Daugherty, A., Murphy, S. J. H., Thakur, C., Trask, D., Ahuja, G., Zhong, Q., Moisan, A., Tiffeau-Mayer, A. & Saligrama, N. & 1 others, Wagar, L. E., Dec 9 2025, In: Immunity. 58, 12, p. 3130-3143.e8Research output: Contribution to journal › Article › peer-review
- BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4+ T cellsGao, H., Li, Y., Tiwari, R., Pinzone, M., Qin, X., Clark, K. M., Nicholson, S. K., Yao, T., Rome, K., Scaglione, M., Bailis, W., Presti, R. M., Sereti, I., Saligrama, N., Wang, L. & Shan, L., Sep 16 2025, In: Cell Reports Medicine. 6, 9, 102311.Research output: Contribution to journal › Article › peer-review
- Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoireRosenberger, L., Hansmann, L., Anastasopoulou, V., Wolf, S. P., Drousch, K., Moewes, C., Feng, X., Cao, G., Huang, J., Yew, P. Y., Strønen, E., Kato, T., Saligrama, N., Olweus, J., Nakamura, Y., Willimsky, G., Blankenstein, T., Schreiber, H. & Leisegang, M., May 2 2025, In: Journal for ImmunoTherapy of Cancer. 13, 5, e011351.Research output: Contribution to journal › Article › peer-review
- Cis-regulatory evolution of the recently expanded Ly49 gene familyFan, C., Xing, X., Murphy, S. J. H., Poursine-Laurent, J., Schmidt, H., Parikh, B. A., Yoon, J., Choudhary, M. N. K., Saligrama, N., Piersma, S. J., Yokoyama, W. M. & Wang, T., Dec 2024, In: Nature communications. 15, 1, 4839.Research output: Contribution to journal › Article › peer-review
- A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in miceA human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in miceToth, K. A., Schmitt, E. G., Kolicheski, A., Greenberg, Z. J., Levendosky, E., Saucier, N., Trammel, K., Oikonomou, V., Lionakis, M. S., Klechevsky, E., Kim, B. S., Schuettpelz, L. G., Saligrama, N. & Cooper, M. A., Aug 5 2024, In: Journal of Experimental Medicine. 221, 8, e20232091.Research output: Contribution to journal › Article › peer-review