Musiek Lab
Erik S. Musiek, MD, PhD
The Musiek lab studies how circadian rhythms and the circadian clock system influence neurodegenerative diseases, in particular Alzheimer’s disease. Research focuses on the molecular mechanisms by which the circadian clock regulates processes such as inflammation, oxidative stress and protein aggregation in cellular and animal models of Alzhiemer’s disease and other age-related neurodegenerative conditions.
Areas of current interest include:
- Circadian clocks in Alzheimer’s Disease pathogenesis
- Regulation of glial function and neuroinflammation by the circadian clock
- Interplay between aging, the circadian clock, and neurodegeneration
- The role of glial cells in neurodegenerative diseases
- Novel therapeutic targets for Alzheimer’s Disease
Principal investigator
Recent publications
- ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleepConstantino, N. J., Carroll, C. M., Williams, H. C., Vekaria, H. J., Yuede, C. M., Saito, K., Sheehan, P. W., Snipes, J. A., Raichle, M. E., Musiek, E. S., Sullivan, P. G., Morganti, J. M., Johnson, L. A. & Macauley, S. L., Feb 25 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 8, e2416578122.Research output: Contribution to journal › Article › peer-review
- Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNIthe LEADS Consortium 1 for the Alzheimer's Disease Neuroimaging Initiative, Jan 2025, In: Alzheimer's and Dementia. 21, 1, e14218.Research output: Contribution to journal › Article › peer-review
- Anti-amyloid treatments: Why we think they are worth itSchindler, S. E., Musiek, E. S. & Morris, J. C., Jan 1 2025, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 11, 1, e70055.Research output: Contribution to journal › Comment/debate
- Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdownLawrence, J. H., Patel, A., King, M. W., Nadarajah, C. J., Daneman, R. & Musiek, E. S., Nov 8 2024, In: JCI Insight. 9, 21, e180081.Research output: Contribution to journal › Article › peer-review
- Editorial overview: Introduction to neurobiology of diseaseMusiek, E. S. & Nestler, E. J., Jun 2024, In: Current Opinion in Neurobiology. 86, 102875.Research output: Contribution to journal › Editorial
- Longer sleep duration in Alzheimer's disease progression: a compensatory response?Li, P., Gao, L., Lucey, B. P., Ju, Y. E. S., Musiek, E. S. & Hu, K., Jun 1 2024, In: Sleep. 47, 6, zsae093.Research output: Contribution to journal › Editorial
- Sleep and circadian biomarkers of postoperative delirium (SLEEP-POD): protocol for a prospective and observational cohort studySugg, E., Gleeson, E., Baker, S. N., Li, P., Gao, C., Mueller, A., Deng, H., Shen, S., Franco-Garcia, E., Saxena, R., Musiek, E. S., Akeju, O., Xie, Z., Hu, K. & Gao, L., Apr 19 2024, In: BMJ Open. 14, 4, e080796.Research output: Contribution to journal › Article › peer-review
- Circadian Biology and the Neurovascular UnitLi, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S. & Lo, E. H., Mar 15 2024, In: Circulation research. 134, 6, p. 748-769 22 p.Research output: Contribution to journal › Article › peer-review
- Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegenerationKanan, M. K., Sheehan, P. W., Haines, J. N., Gomez, P. G., Dhuler, A., Nadarajah, C. J., Wargel, Z. M., Freeberg, B. M., Nelvagal, H. R., Izumo, M., Takahashi, J. S., Cooper, J. D., Davis, A. A. & Musiek, E. S., Jan 2024, In: JCI Insight. 9, 2, e162771.Research output: Contribution to journal › Article › peer-review
- Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADSthe LEADS Consortium, 2024, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review