Kotzbauer Lab
Paul Kotzbauer, MD, PhD
Advances research on neurodegenerative diseases, focusing on Parkinson’s disease and infantile neuroaxonal dystrophy. The lab investigates alpha-synuclein aggregation, neuronal connectivity and enzyme dysfunction to develop Our research group is driven by the intricate complexity of the human brain. To address the challenges of studying brain organization and function, we have developed a multi-faceted research strategy that integrates advanced imaging, behavioral science and computational methods.
Principal investigator
Our team
Recent publications
- Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy studyMiller, R., O'Shea, J., Rosok, L. M., Lim, S., Franklin, E. E., Perrin, R., Hwang, H., Dhavale, D., Perlmutter, J., Campbell, M. C. & Kotzbauer, P., Oct 2026, In: Alzheimer's and Dementia. 22, 10, e71868.Research output: Contribution to journal › Article › peer-review
- Study of blood linear RNA nominates CD55 and DLD as early-stage biomarkers for Parkinson's diseaseBeric, A., Sahin, S., Sanchez, S., Yang, Z., Kumar, R., Alfradique-Dunham, I., Sanford, J., Western, D., Phillips, B., Budde, J. P., Perrin, R., Kotzbauer, P. T., Perlmutter, J. S., Norris, S., Cruchaga, C. & Ibanez, L., Oct 2026, In: Brain. 149, 10, p. 3509-3523 15 p.Research output: Contribution to journal › Article › peer-review
- Blood-based circular RNAs for early diagnosis of Alzheimer’s diseasePhillips, B., Sanford, J., Janve, V. A., Liu, M., Johnson, M., Gong, K., Bergmann, K., Lowery, J., Flynn, A., Brock, W., Montejo, B. S., Sykora, N., Budde, J., Mellios, N., Papageorgiou, G., Sperling, R. A., Buckley, R. F., Seto, M., Morris, J. C. & Perlmutter, J. S. & 5 others, Kotzbauer, P. T., Perrin, R. J., Hohman, T. J., Ibanez, L. & Cruchaga, C., Aug 2026, In: Nature medicine. 32, 8, p. 2857-2864 8 p.Research output: Contribution to journal › Article › peer-review
- In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key FoldMilchberg, M. H., Warmuth, O. A., Borcik, C. G., Han, R., Harding, B. D., DeZonia, B., Dhavale, D. D., Pierson, J. A., Kotzbauer, P. T., Wright, E. R., Schwieters, C. D. & Rienstra, C. M., Jul 16 2026, In: Journal of Physical Chemistry B. 130, 28, p. 7120-7133 14 p.Research output: Contribution to journal › Article › peer-review
- Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseasesKnight Alzheimer Disease Research Center (Knight ADRC), Alzheimer Disease Neuroimaging Initiative (ADNI), Fundació ACE Alzheimer Center Barcelona (FACE), Barcelona-1, Stanford Alzheimer Disease Research Center (Stanford ADRC) & The Global Neurodegeneration Proteomics Consortium (GNPC), Jul 15 2026, In: Neuron. 114, 14, p. 2549-2565.e7Research output: Contribution to journal › Article › peer-review