Cross Lab

Anne Cross, MD

MRI photo left to right Rob Naismith, MD, Anne Cross, MD, Victor Song, PhD, and Robyn Klein, MD Shot for Outlook Magazine
MRI photo left to right Rob Naismith, MD, Anne Cross, MD, Victor Song, PhD, and Robyn Klein, MD Shot for Outlook Magazine

The goal of the Cross lab’s research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (brain and spinal cord). Our research is primarily focused on the human disease multiple sclerosis (MS), which is very common (1/1000 in the U.S. population). We study human tissues (blood, DNA, RNA, spinal fluid) and perform cutting-edge imaging of the human nervous system. We sometimes employ an animal model for MS known as experimental autoimmune encephalomyelitis (EAE). We are currently performing longitudinal imaging studies to help devise methods to differentiate the various types of pathologies in the human disease, such as demyelination, inflammation with cells and or edema due to blood-brain barrier breakdown and axon damage and loss. We are funded to devise better methods to measure progression of MS over time, which might be used in clinical trials. We also study the effects of diet and calorie restriction upon neuro-inflammation, having shown previously that calorie restriction ameliorates EAE, the prime animal model for MS, at least partly through the upregulation of adiponectin and downregulation of leptin.

Principal investigator

Anne H. Cross, MD

Anne H. Cross, MD

Professor of Neurology
Chief, Adult Neuroimmunology
Manny and Rosalyn Rosenthal – Dr. John Trotter MS Center Chair in Neuroimmunology


  Cross lab

 
Top areas of adult care: multiple sclerosis, transverse myelitis, MOGAD

Research profile
Clinical profile

Recent publications

  • Cerebrospinal fluid biomarkers as predictors of multiple sclerosis severity
    Cerebrospinal fluid biomarkers as predictors of multiple sclerosis severityTolentino, M., Pace, F., Perantie, D. C., Mikesell, R., Huecker, J., Chahin, S., Ghezzi, L., Piccio, L. & Cross, A. H., Feb 2025, In: Multiple Sclerosis and Related Disorders. 94, 106268.Research output: Contribution to journal › Article › peer-review
  • A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
    A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populationsCantoni, C., Smirnov, R. A., Firulyova, M., Andhey, P. S., Bradstreet, T. R., Esaulova, E., Terekhova, M., Schwarzkopf, E. A., Abdalla, N. M., Kleverov, M., Sabatino, J. J., Liu, K., Schwab, N., Meyer Zu Hörste, G., Cross, A. H., Artyomov, M. N., Edelson, B. T. & Wu, G. F., Jan 2 2025, In: Journal of Clinical Investigation. 135, 1, e177793.Research output: Contribution to journal › Article › peer-review
  • Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials
    Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trialsMontalban, X., Vermersch, P., Arnold, D. L., Bar-Or, A., Cree, B. A. C., Cross, A. H., Kubala Havrdova, E., Kappos, L., Stuve, O., Wiendl, H., Wolinsky, J. S., Dahlke, F., Le Bolay, C., Shen Loo, L., Gopalakrishnan, S., Hyvert, Y., Javor, A., Guehring, H., Tenenbaum, N. & Tomic, D., Nov 2024, In: The Lancet Neurology. 23, 11, p. 1119-1132 14 p.Research output: Contribution to journal › Article › peer-review
  • MS treatment de-escalation: review and commentary
    MS treatment de-escalation: review and commentarySelmaj, K., Hartung, H. P., Mycko, M. P., Selmaj, I. & Cross, A. H., Oct 2024, In: Journal of Neurology. 271, 10, p. 6426-6438 13 p.Research output: Contribution to journal › Review article › peer-review
  • Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI
    Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRISamara, A., Xiang, B., Judge, B., Ciotti, J. R., Yablonskiy, D. A., Cross, A. H. & Brier, M. R., Oct 2024, In: Multiple Sclerosis and Related Disorders. 90, 105834.Research output: Contribution to journal › Article › peer-review
Complete bibliography