Cross Lab
Anne Cross, MD
The goal of the Cross lab’s research is to understand the mechanisms involved in pathogenesis of inflammation and demyelination in the central nervous system (brain and spinal cord). Our research is primarily focused on the human disease multiple sclerosis (MS), which is very common (1/1000 in the U.S. population). We study human tissues (blood, DNA, RNA, spinal fluid) and perform cutting-edge imaging of the human nervous system. We sometimes employ an animal model for MS known as experimental autoimmune encephalomyelitis (EAE). We are currently performing longitudinal imaging studies to help devise methods to differentiate the various types of pathologies in the human disease, such as demyelination, inflammation with cells and or edema due to blood-brain barrier breakdown and axon damage and loss. We are funded to devise better methods to measure progression of MS over time, which might be used in clinical trials. We also study the effects of diet and calorie restriction upon neuro-inflammation, having shown previously that calorie restriction ameliorates EAE, the prime animal model for MS, at least partly through the upregulation of adiponectin and downregulation of leptin.
Principal investigator
Anne H. Cross, MD
Professor of Neurology
Chief, Adult Neuroimmunology
Manny and Rosalyn Rosenthal – Dr. John Trotter MS Center Chair in Neuroimmunology
- Phone: 314-362-3293
Recent publications
- Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis PatientsBrier, M. R., Schindler, S. E., Salter, A., Perantie, D., Shelley, N., Judge, B., Keefe, S., Kirmess, K. M., Verghese, P. B., Yarasheski, K. E., Venkatesh, V., Raji, C. A., Gordon, B. A., Bateman, R. J., Morris, J. C., Naismith, R. T., Holtzman, D. M., Benzinger, T. L. S. & Cross, A. H., Sep 2024, In: Annals of neurology. 96, 3, p. 453-459 7 p.Research output: Contribution to journal › Article › peer-review
- Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restrictionMartin, K., Cofield, S. S., Cross, A. H., Goss, A. M., Raji, C. A., Rinker, J. R., Wu, G. F., Blair, J., Fuchs, A., Ghezzi, L., Green, K., Pace, F., Pastori, G., Taylor, M. G., Piccio, L. & Wingo, B. C., Aug 2024, In: Contemporary Clinical Trials. 143, 107584.Research output: Contribution to journal › Article › peer-review
- Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseasesTrivedi, R. R., Archambault, A. S., Pavlak, C., Gastaldi, M., Cantoni, C., Ghezzi, L., Cross, A. H., Miller, T. M. & Wu, G. F., Jun 15 2024, In: Journal of the Neurological Sciences. 461, 123041.Research output: Contribution to journal › Article › peer-review
- Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple SclerosisCross, A. H., Gelfand, J. M., Thebault, S., Bennett, J. L., Von Büdingen, H. C., Cameron, B., Carruthers, R., Edwards, K., Fallis, R., Gerstein, R., Giacomini, P. S., Greenberg, B., Hafler, D. A., Ionete, C., Kaunzner, U. W., Kodama, L., Lock, C., Longbrake, E. E., Musch, B. & Pardo, G. & 13 others, Piehl, F., Weber, M. S., Yuen, S., Ziemssen, T., Bose, G., Freedman, M. S., Anania, V. G., Ramesh, A., Winger, R. C., Jia, X., Herman, A., Harp, C. & Bar-Or, A., Apr 8 2024, In: JAMA […]
- Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosisWooliscroft, L., Salter, A., Adusumilli, G., Levasseur, V. A., Sun, P., Lancia, S., Perantie, D. C., Trinkaus, K., Naismith, R. T., Song, S. K. & Cross, A. H., Apr 2024, In: Multiple Sclerosis and Related Disorders. 84, 105494.Research output: Contribution to journal › Article › peer-review