Katie Cammarata | Page 40 | Neurology | Washington University in St. Louis

Rainwater Charitable Foundation Announces Second-Annual Rainwater Prize Winners for Brain Research (Links to an external site)

February 22, 2021June 28, 2022

FORT WORTH, Texas, Feb. 22, 2021 /PRNewswire/ — The Rainwater Charitable Foundation, one of the largest independent funders of neurodegenerative disease research, today announced Dr. David M. Holtzman (the Andrew B. and Gretchen P. Jones Professor and Chair of Neurology, Washington University School of Medicine in St. Louis) and Dr. Celeste Karch (Associate Professor of Psychiatry, […]

Protein linked to Alzheimer’s, strokes cleared from brain blood vessels (Links to an external site)

February 17, 2021June 28, 2022

Amyloid deposits (blue) in mouse brain tissue and blood vessels are reduced after treatment with an antibody that targets the protein APOE (right), a minor component of amyloid deposits, compared to a placebo antibody (left). Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds.

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise […]

Fauci to discuss COVID-19 during online med school event Jan. 7 (Links to an external site)

January 4, 2021June 28, 2022

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH), will give an online talk to the Washington University Medical Campus community on Thursday, Jan. 7. The talk will be available online to the public.

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH), will give the Gerald Medoff Visiting Professor lecture at Washington University School of Medicine in St. Louis on Thursday, Jan. 7. The session will be delivered online.

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm (Links to an external site)

December 16, 2020June 28, 2022

Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that links the amyloid-removal process to the circadian clock. The protein, YKL-40, could help explain why people with Alzheimer’s frequently suffer from sleep disturbances, and provide a new target for Alzheimer’s therapies.

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood.

Construction progresses on neuroscience research building (Links to an external site)

December 3, 2020June 28, 2022

The neuroscience research building’s basement lies in a hole 25 feet deep and 400 feet long, dug at the southeast corner of Duncan and Newstead avenues. More than 106 drilled concrete piers have been poured, and the interior columns and floor in the western half of the basement have been completed. (Photo: Matt Miller/School of Medicine)

Washington University School of Medicine’s eastern border began noticeably changing in April and will look strikingly different in 2023, when the neuroscience research building — 11 stories tall and 609,000 square feet — is complete. The building project, the largest in the medical school’s history, will span almost a block in the 200-acre Cortex Innovation […]

Why doesn’t deep-brain stimulation work for everyone? (Links to an external site)

December 10, 2019June 28, 2022

Brain networks corresponding to functions such as vision (blue) and attention (green) mingle and share information in structures deep inside the brain, as seen, for example, in the bottom right corner of this color-coded composite MRI image. Researchers at Washington University School of Medicine in St. Louis have mapped nine functional networks in the deep-brain structures of 10 healthy people, an accomplishment that could lead to improvements in deep-brain stimulation therapy for severe cases of Parkinson’s disease and other neurological conditions. (Image: Scott Marek)

People with severe Parkinson’s disease or other neurological conditions that cause intractable symptoms such as uncontrollable shaking, muscle spasms, seizures, obsessive thoughts and compulsive behaviors are sometimes treated with electric stimulators placed inside the brain. Such stimulators are designed to interrupt aberrant signaling that causes the debilitating symptoms. The therapy, deep-brain stimulation, can provide relief […]

Alzheimer’s researchers receive Chan Zuckerberg Initiative funding (Links to an external site)

December 5, 2019June 28, 2022

A team of Washington University researchers is receiving a Chan Zuckerberg Initiative award to support their research into the immune system's potential role in combating Alzheimer's disease. They are (from left) Carlos Cruchaga, PhD; Gregory Day, MD; Celeste Karch, PhD; and Oscar Harari, PhD.

A team of researchers at Washington University School of Medicine in St. Louis has been funded by the Chan Zuckerberg Initiative (CZI) to study the root causes of neurodegenerative disorders.

A Rare Variant of APOE Delays Alzheimer’s Disease Onset By Decades<br>Now the Field Is Focused on Learning How (Links to an external site)

December 5, 2019June 28, 2022

A woman with a rare variant of APOE and familial Alzheimer’s disease (AD) had delayed development of AD by nearly 30 years. Independent researchers said the report is changing the thinking and focus of research about the biology of APOE in AD.

Microglia Deletion Protects Against Tau Pathology in Alzheimer’s Mice (Links to an external site)

November 21, 2019June 28, 2022

Microglia are the driving force of neurodegeneration in a tauopathy mouse model, a new animal study found. The authors of the report suggest microglia may be an effective therapeutic target for preventing disease progression in the setting of tauopathy.

Major Alzheimer’s study to open 5 new Latin American sites (Links to an external site)

November 19, 2019June 28, 2022

A major international Alzheimer's research study is opening five new sites in Latin America. The sites will increase the diversity of the study population and aid efforts to understand the development of Alzheimer's in Latino populations.

A major international Alzheimer’s disease research initiative will open five new sites in Latin America to help researchers understand the development of early-onset Alzheimer’s in Latino populations.