Roe Lab

My overarching research interest is to address novel questions about Alzheimer’s disease (AD) via secondary data analysis of preexisting databases, some of which are underutilized. Use of archival data presents a number of advantages, including relatively inexpensive and rapid acquisition of data, large numbers of participants, and the ability to look at longitudinal questions using data spanning decades or more. Potential disadvantages include the fact that the data were often gathered for another purpose, incompleteness of data documentation, and difficulty in judging the data quality. My specific areas of interest currently include study of how cognitive reserve impacts the clinical expression of dementia symptoms among individuals with AD pathology, and how cancer might be related to AD risk.

Principal investigator

Catherine Roe, PhD

Associate Professor, Neurology

Recent publications

• Naturalistic driving measures of route selection associate with resting state networks in older adults
  December 1, 2022
  Naturalistic driving measures of route selection associate with resting state networks in older adultsWisch, J. K., Roe, C. M., Babulal, G. M., Metcalf, N., Johnson, A. M., Murphy, S., Hicks, J., Doherty, J. M., Morris, J. C. & Ances, B. M., Dec 2022, In: Scientific reports. 12, 1, 6486.Research output: Contribution to journal › Article › peer-review
• Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer's disease
  June 13, 2022
  Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer's diseaseDoherty, J. M., Roe, C. M., Murphy, S. A., Johnson, A. M., Fleischer, E., Toedebusch, C. D., Redrick, T., Freund, D., Morris, J., Schindler, S., Fagan, A. M., Holtzman, D. M., Lucey, B. P. & Babulal, G. M., Jun 13 2022, In: Sleep. 45, 6Research output: Contribution to journal › Article › peer-review
• Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
  March 1, 2022
  Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical SpectrumJansen, W. J., Janssen, O., Tijms, B. M., Vos, S. J. B., Ossenkoppele, R., Visser, P. J., Aarsland, D., Alcolea, D., Altomare, D., Von Arnim, C., Baiardi, S., Baldeiras, I., Barthel, H., Bateman, R. J., Van Berckel, B., Binette, A. P., Blennow, K., Boada, M., Boecker, H., Bottlaender, M., & 162 othersDen Braber, A., Brooks, D. J., Van Buchem, M. A., Camus, V., Carill, J. M., Cerman, J., Chen, K., Chételat, G., Chipi, E., Cohen, A. D., Daniels, A., Delarue, M., Didic, M., Drzezga, A., Dubois, B., Eckerström, M., Ekblad, […]
• Limited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer Disease
  January 1, 2022
  Limited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer DiseaseLevine, T. F., Roe, C. M., Babulal, G. M., Fagan, A. M. & Head, D., Jan 1 2022, In: Alzheimer disease and associated disorders. 36, 1, p. 15-21 7 p.Research output: Contribution to journal › Article › peer-review
• The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity
  January 1, 2022
  The complex relationship between depression and progression to incident cognitive impairment across race and ethnicityBabulal, G. M., Zhu, Y., Roe, C. M., Hudson, D. L., Williams, M. M., Murphy, S. A., Doherty, J., Johnson, A. M. & Trani, J. F., 2022, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review